Non-aqueous formulations for ram and screen extrusion-spheronisation

Publication date: Available online 11 February 2019Source: International Journal of PharmaceuticsAuthor(s): M. Zhang, S.L. Rough, R. Ward, C. Seiler, D.I. WilsonAbstractThe use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing non-aqueous pastes. Preliminary tests were performed on a series of pastes using a ram as well as a laboratory roller screen extruder, since the former is commonly used in batch testing and the latter replicates the shear range in a manufacturing screen extruder. Pellets with acceptable size and shape distributions were obtained with Avicel® HFE-102 NF/HPC/IPA for ram E-S, and with Avicel® RC-591/HPC/IPA for screen E-S. Further investigation was performed with calcium carbonate added as a model active pharmaceutical ingredient. Both formulations were able to generate pellets with acceptable size and shape characteristics at up to 50 wt% carbonate loading: further work is required to optimise yields.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Journal of Medicinal Food, Ahead of Print.
Source: Journal of Medicinal Food - Category: Nutrition Authors: Source Type: research
Publication date: Available online 19 November 2019Source: Journal of Membrane ScienceAuthor(s): Yadong Zhu, Xufeng Yu, Tonghui Zhang, Peiyun Li, Xuefen WangAbstractBiomacromolecules and their assemblies exhibit the great potential for biomimetic construction of novel and functional nanomaterials. In this work, sulfated silk nanofibrils (SSNFs) were firstly prepared with special designed sulfated silk fibroin molecule by a facile self-assembly technique, which were incorporated into the poly (vinyl alcohol) (PVA) hydrogel. Then they were together coated on the electrospun polyacrlonitrile (PAN) nanofibrous scaffold to fabr...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Publication date: Available online 19 November 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Aditya Rianjanu, Kuwat Triyana, Doni B. Nugroho, Ahmad Kusumaatmaja, Roto RotoAbstractAnalytical parameters including sensitivity in the QCM sensing system are critical to understand its sensing mechanism. We investigated the QCM analytical parameters after the QCM electrode surface was modified with polyvinyl acetate (PVAc) nanofiber for primary alcohols’ vapor detection. The PVAc nanofibers were prepared by electrospinning method and were observed using a scanning electron microscope (SEM). The modified QCM sensin...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
Publication date: Available online 20 November 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Vu Dang Hoang, Hung Huu Tran, Cao Cong Phuong, Hue Minh Thi Nguyen, Toan T. NguyenAbstractComputer simulations using atomistic model are carried out to investigate the stability of ternary systems of pure or mixed fatty alcohols, cetrimide, and water. These semi−solid oil-in-water systems are used as the main component of pharmaceutical creams. Experiments show that the mixed alcohol systems are more stable than pure ones. The current experimental hypothesis is that this is the result of the length mismatc...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Abstract Anesthesia providers have the burden of constant hand hygiene during task dense periods. The requirement for hand hygiene often demands frequent application of alcohol-based hand rub. To assess whether frequent alcohol-based hand rub use leads to skin changes or irritant contact dermatitis, volunteers cleaned their hands with alcohol-based hand rub every 15 minutes for 8 hours for 5 sequential days. They were examined by a dermatologist before and after and asked about subjective skin changes. Results suggest an increase in irritant contact dermatitis scores and subjective complaints. PMID: 31743176 ...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
CONCLUSIONS: This study suggests that the use of alcohol-based hand rub on commonly used nitrile examination gloves does not compromise glove integrity or hamper the ability to safely perform routine anesthesia functions. PMID: 31743175 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Abstract BACKGROUND: Frequent hand hygiene by anesthesia personnel may be an important factor in reducing contamination of IV lines and medication access ports and may reduce hospital-acquired infections. Measurement of hand hygiene frequency at the individual clinician level by direct observation or electronic devices is cumbersome and expensive. We developed and validated a simple method for estimating hand hygiene frequency by individual anesthesia providers and utilized it in a quality improvement initiative to increase hand hygiene use. METHODS: Pump-style, alcohol-based hand hygiene container weight at ...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
In this study, the modification of cellulose derivative namely carboxymethyl cellulose (CMC) blended with polyvinyl alcohol (PVA) and doped with different content of NH4Br based solid polymer electrolytes (SPEs) prepared via solution casting method is investigated. The FTIR analysis demonstrated the interaction between CMC-PVA and NH4Br via COO−. The optimum ionic conductivity at ambient temperature is found to be 3.21 × 10−4 S/cm for the sample containing 20 wt% NH4Br with the lowest percentage of crystallinity and total weight loss. The conductivity-temperature relationship for the entire SPEs s...
Source: Polymer Testing - Category: Chemistry Source Type: research
Publication date: Available online 19 November 2019Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): Michael Bingham, Andrew MillsAbstractA number of different M/TiO2 photocatalysts, where M (the co-catalyst) = Pt, Pd, Au and Ag, are used to drive the steam reforming of methanol (MeOH) in a gas phase continuous flow reactor operated at 100 °C. The rate of H2 production is: Pt > Pd > Au > Ag>> no metal. The photonic efficiency of Pt/TiO2 photocatalyst is ca. 120% which suggests some of the hydrogen derives from a current-doubling rea...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
We report herein a ligand and additive- free [CuNi(bz)3(bpy)2]ClO4 catalyst system that efficiently and selectively catalyses the oxidation of a range of primary and secondary benzylic alcohols, 1 – heteroaryl alcohols, cinnamyl alcohol, and aliphatic alcohols mediated by hydrogen peroxide to the corresponding aldehydes and ketones, respectively.Graphical abstractHeterobimetallic copper-zinc coordination complex as an efficient catalyst for the oxidation of alcohols to aldehydes under mild condition in water in 30 % aqueous H2O2.
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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