Burden of Chagas disease in Brazil, 1990-2016: findings from the Global Burden of Disease Study 2016.

Burden of Chagas disease in Brazil, 1990-2016: findings from the Global Burden of Disease Study 2016. Int J Parasitol. 2019 Feb 07;: Authors: Martins-Melo FR, Carneiro M, Ribeiro ALP, Bezerra JMT, Werneck GL Abstract Chagas disease continues to be an important cause of morbidity, mortality and disability in several Latin American countries including Brazil. Using findings from the Global Burden of Disease Study 2016 (GBD 2016), we present years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) due to Chagas disease in Brazil, by sex, age group, and Brazilian states, from 1990 to 2016. Results are reported in absolute numbers and age-standardized rates (per 100,000 population) with 95% uncertainty intervals (UIs). In 2016, 141,640 DALYs (95% UI: 129,065-155,941) due to Chagas disease were estimated in Brazil, with a relative reduction of 36.7% compared with 1990 (223,879 DALYs (95% UI: 209,372-238,591)). Age-standardized DALY rates declined at the national level (-69.7%) and in all Brazilian states between 1990 and 2016, but with different regional patterns. The decrease in the DALY rates was driven primarily by a consistent reduction in the YLL rates, the main component of total DALYs for Chagas disease. The highest fatal and non-fatal burden due to Chagas disease was observed among males, the elderly, and in those Brazilian states encompassing important endemic areas for vector trans...
Source: International Journal for Parasitology - Category: Parasitology Authors: Tags: Int J Parasitol Source Type: research