Exenatide once-weekly improves metabolic parameters, endothelial dysfunction and carotid intima-media thickness in patients with type-2 diabetes: an 8-month prospective study

Type 2 diabetes mellitus is a multiple etiology metabolic disorder characterized by chronic hyperglycemia in subjects with insulin resistance. This chronic hyperglycemia results in altered insulin secretion, reduced glucose utilization, and increased liver glucose production [1,2]. Persons with type 2 diabetes mellitus are usually overweight and obese [3] and they frequently have high blood pressure, dyslipidemia and, ultimately, a significantly elevated risk of cardiovascular (CV) diseases [4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research

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Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Abstract Much of the cardiovascular disease burden and mortality can be traced back to four adverse health behaviors (smoking, poor diet, elevated body mass index, sedentary lifestyle) and three major risk factors (hypercholesterolemia, hypertension, diabetes). Ideal cardiovascular health defined as having all seven factors at goal is very rare among US adults. It is estimated that 87% of middle-aged US adults and 95% of individuals ≥60 years old meet ≤4 of these health metrics.1 Detailed guidelines are available that discuss cardiovascular risk assessment, lifestyle management, and treatment of individual r...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
In this study, the synergistic/additive effects of combined supplementations with blueberry and yoghurt, and C3G and peptides were determined. Blueberry and yoghurt alone, and the combination of C3G and peptides significantly reduced both systolic and diastolic blood pressure in diet-induced obese mice. Yoghurt supplementation significantly reduced body weight, percentage body fat and improved intraperitoneal glucose tolerance. Furthermore, peptides and the combination of peptides and C3G resulted in a significant reduction of percentage body fat and improved intraperitoneal glucose tolerance. As widely available, safe and...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 8 March 2019Source: Molecular Aspects of MedicineAuthor(s): Fabián Pardo, Mario Subiabre, Gonzalo Fuentes, Fernando Toledo, Luis Silva, Roberto Villalobos-Labra, Luis SobreviaAbstractObesity and type 2 diabetes mellitus (T2DM) are diseases associated with hypertension and metabolic alterations. A significant group of patients present both obesity and T2DM, a condition defined as diabesity. One of the metabolic features in these conditions is the clinical presentation of insulin resistance. Several tissues, including the liver, skeletal muscle, and vasculature, and patients with T2D...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
This study determines the prevalence of pre-diabetes and type 2 diabetes mellitus among commercial taxi drivers in Buffalo City Metropolitan Municipality (BCMM), Eastern Cape and examines the factors associated with type 2 diabetes mellitus. A cross-sectional survey of 403 commercial taxi drivers was undertaken using the World Health Organization (WHO) STEPwise approach. Anthropometric, blood pressure, and blood glucose measurements followed standard procedure. Diabetes status was determined using the fasting blood glucose (FBG) test. Diabetes was defined as a FBG ≥7.0mmol/L or self-reported history of diabetes or curr...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Background: Laparoscopic adjustable gastric banding (LAGB) and laparoscopic sleeve gastrectomy (LSG) are common weight loss procedures. Our meta-analysis compared these procedures for the treatment of morbid obesity and related diseases. Methods: We systematically searched the PubMed, Embase, and the Cochrane Library through January 2018. The percentage of excess weight loss (%EWL), improvement or remission of type 2 diabetes mellitus (T2DM) and hypertension were analyzed and compared. Results: Thirty-three studies with 4109 patients were included. Greater decreases in excess weight were found in patients who recei...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Authors: Spallone V Abstract The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Efforts to overcome CAN under-diagnosis are on the table: by promoting screening for symptoms and signs; by ...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
AbstractObesity is a severe worldwide epidemic. Obesity comorbidities, such as type 2 diabetes mellitus, hypertension, and atherosclerosis, are costly for patients and governments. The treatment of obesity involves several facets, including lifestyle changes, bariatric surgery, and pharmacotherapy. As changes in lifestyle require considerable patient commitment that is sometimes unachievable, and surgery is expensive and invasive, pharmacotherapy is the primary option for most patients. This review describes the pharmacotherapy currently available in the USA, Europe, and Brazil, focusing on its limitations. We then analyze...
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Morbid obesity has been defined by the WHO as a global epidemic. The incidence of obesity among the renal transplant population is on the rise, with obesity-mediated diseases, such as type 2 diabetes mellitus (T2D), dyslipidemia and hypertension, being considered the leading causes of end-stage renal disease. Moreover, gaining weight after transplantation is a very common occurrence in most kidney transplant patients [1], and obesity is an independent risk factor for chronic renal failure [2].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
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