BioethicsTV (February 4-8, 2019): #TheResident, #TheGoodDoctor, #ChicagoMed, #GreysAnatomy

by Craig Klugman, Ph.D. Jump to The Resident (Season 2; Episode 13): A risky organ transplant; Jump to The Good Doctor (Season 2; Episode 14):Face Transplant; Jump to Chicago Med (Season 4; Episode 13): Suspecting the worst; HIV safety or stigmatization; Suspicion and stealing from patients; Jump to Greys Anatomy (Season 15; Episode 12): Removing Dying Patient’s Autonomy The Resident (Season 2; Episode 13): A risky organ transplant Eloise is a third year medical student in need of a double lung transplant as a result of her cystic fibrosis.…
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: BioethicsTV Decision making End of Life Care Featured Posts HIV/AIDS Informed Consent Organ Transplant & Donation Privacy Source Type: blogs

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Improved lung function, increased BMI, reduced need for IV antibiotics seen after one year of therapy
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Pediatrics, Pharmacy, Pulmonology, Journal, Source Type: news
FRIDAY, Oct. 11, 2019 -- After one year of therapy with lumacaftor-ivacaftor in a real-world setting, adolescents and adults with cystic fibrosis and Phe508del homozygous mutation experienced an improvement in lung function, increase in body mass...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
BackgroundThere is a paucity of data evaluating antibiotic use in anterior skull ‐base surgery (ASBS). The goal of this study was to determine antibiotic prescribing patterns and factors that influence antibiotic use in ASBS.MethodsAn online ‐based survey was distributed to the membership of the North American Skull Base Society in 2018. Outcomes included practitioner preference regarding intraoperative and postoperative antibiotic use, practice location and environment, surgeon experience, and patient factors influencing antibiotic u se.ResultsThere were 208 respondents (25.6% response rate) of which 182 (87.5%) perfo...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
New variables ID the sickest waitlist candidates with cystic fibrosis, chronic obstructive pulmonary disease
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Pulmonology, Surgery, Journal, Source Type: news
CONCLUSIONS: We were unable to identify RCTs with evidence which would support healthcare policy-making and practice related to implementation of shared decision-making for children and adolescents (aged between four and 18 years) with CF). We hope that having identified this gap in research, awareness will increase amongst researchers of the need to design high-quality shared decision-making interventions for young people with CF, perhaps adapted from existing models for adults, and to test these interventions and children's preferences in RCTs. It is also important to target health professionals with evidence-based educa...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Publication date: Available online 7 May 2019Source: Microbiological ResearchAuthor(s): Jobina Rajkumari, Subhomoi Borkotoky, Dhanasekhar Reddy, Saswat Kumar Mohanty, Ranjith Kumavath, Ayaluru Murali, Kitlangki Suchiang, Siddhardha BusiAbstractPseudomonas aeruginosa is one of the most common pathogens associated with nosocomial infections and a great concern to immunocompromised individuals especially in the cases of cystic fibrosis, AIDS and burn wounds. The pathogenicity of P. aeruginosa is largely directed by the quorum sensing (QS) system. Hence, QS may be considered an important therapeutic target to combat P. aerugin...
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract BACKGROUND: Appetitive characteristics are an important factor in the nutritional status of children with cystic fibrosis (CF). We administered a brief parent-report eating behavior questionnaire, validated in healthy children, to determine the relationship between appetitive characteristics and body weight in children with CF. METHODS: Parents of children attending the Johns Hopkins Pediatric CF Clinic completed the Child Eating Behavior Questionnaire (CEBQ) at a routine clinic visit. Responses were correlated with anthropometric and other clinical data. RESULTS: Parents of 64 children with CF ...
Source: Appetite - Category: Nutrition Authors: Tags: Appetite Source Type: research
AbstractPurpose of ReviewMycobacterium kansasii is a slow-growing member of the nontuberculous mycobacterial species that manifests clinically with pulmonary, cutaneous, or disseminated forms. Most cases ofM. kansasii infection occur in immunocompromised hosts including HIV/AIDS, solid-organ transplantation, anti-interferon- γ antibody disorder, or among those with pulmonary disorders such as chronic obstructive pulmonary disease or cystic fibrosis. In this review, we aim to discuss relevant literature regarding the clinical manifestations of this infection with a particular emphasis on the clinical spectrum and trea...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
Abstract Plasmid DNA (pDNA) is an attractive therapeutic biomolecule in several diseases including cancer, AIDS, cystic fibrosis, Parkinson's disease and Alzheimer's disease. Increasing demand for plasmid DNA as a therapeutic biomolecule for transgene expression or vaccine applications necessitate novel approaches to bioprocessing. We previously described the synthesis, characterization and evaluation of aminoglycoside-derived hydrogel microbeads ("Amikabeads") for pDNA binding. Here, we describe the generation and evaluation of novel chemotherapeutic drug-conjugated microbeads for application in pDNA bi...
Source: Biotechnology Journal - Category: Biotechnology Authors: Tags: Biotechnol J Source Type: research
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