Repeat breast-conserving therapy for ipsilateral breast cancer recurrence: A systematic review

Publication date: Available online 10 February 2019Source: European Journal of Surgical OncologyAuthor(s): Coco J.E.F. Walstra, Robert-Jan Schipper, Ingrid G.M. Poodt, Yvonne E. van Riet, Adri C. Voogd, Maurice J.C. van der Sangen, Grard A.P. NieuwenhuijzenAbstractThe standard of care for patients with an ipsilateral breast tumour recurrence (IBTR) after breast-conserving therapy (BCT) is a salvage mastectomy. However, there is growing interest in the feasibility of repeat BCT for these patients. This systematic review contains the latest insights on BCT options for patients with an IBTR after initial BCT.A PubMed literature search was performed for articles on BCT options for IBTR after primary lumpectomy followed by radiotherapy. Weighted estimates were calculated for 5- and 10-year local control, distant metastasis-free and overall survival rates. Secondary outcomes were toxicity, cosmesis and quality of life.In total, 34 studies were eligible for analysis, of which 5 reported on repeat breast-conserving surgery (BCS) alone, 10 with mixed populations (BCS ± RT and/or mastectomy), 18 on repeat BCS followed by re-irradiation (whole-breast or partial) and one on quality of life. The weighted estimates for 5-year overall survival for repeat BCS and repeat BCS followed by reirradiation were 77% and 87%, respectively. Five-year local control was 76% for repeat BCS alone and 89% for repeat BCS followed by re-irradiation. Grade III-IV toxicity rates after re-irradiation varie...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research