Powder die filling under gravity and suction fill mechanisms
Publication date: Available online 10 February 2019Source: International Journal of PharmaceuticsAuthor(s): R. Baserinia, I.C. SinkaAbstractIn pharmaceutical tablet manufacturing, the powder formulation is filled into a die and compacted into a tablet using rigid punches. Die fill is important because it limits the productivity of tablet presses and determines key quality attributes of tablets including weight and content uniformity.Die fill occurs due to gravity and suction fill mechanisms. A model linear shoe-die filling system has been instrumented with pressure measurement devices for detailed characterisation of air pressure evolution as the powder mass is delivered in the die. Systematic experiments were carried out using a range of microcrystalline cellulose powders to explore the role of powder properties (such as particle size and bulk density) and operating parameters (such as shoe and die geometry, shoe and suction punch kinematics and powder filling level) on powder delivery. Existing models were found inadequate to describe the mass flow rate of powders under a diversity of gravity and suction filling conditions. The pressure measurements enabled the development of a new die fill model using the Buckingham Π theorem. The model includes separate terms for the contribution of the mass of powder delivered under gravity and suction fill mechanisms. The experimental procedures required to extract model parameters are described. The model is applicable to the handli...
Authors: Kara SD, Amin U, Benbadis SR PMID: 31747527 [PubMed - as supplied by publisher]
ConclusionWe provide an overview of mortality related to SE in China as the HQMS database covers a large number of cases of SE in China, making it one of the most efficient tools for mortality investigation. The use of electronic medical records in China creates several challenges and here we discuss lessons learned. The methodology will be improved and will be used in future studies.
Publication date: Available online 20 November 2019Source: The Lancet NeurologyAuthor(s): Jules Morgan
Publication date: Available online 20 November 2019Source: The Lancet NeurologyAuthor(s): Zenobia Zaiwalla
Publication date: Available online 21 November 2019Source: NeuropsychologiaAuthor(s): Mikko Hurme, Mika Koivisto, Linda Henriksson, Henry RailoAbstractSome neurological patients with primary visual cortex (V1) lesions can guide their behavior based on stimuli presented to their blind visual field. One example of this phenomenon is the ability to discriminate colors in the absence of awareness. These so-called patients with blindsight must have a neural pathway that bypasses V1, explaining their ability to unconsciously process stimuli. The pathways that have been most often hypothesized to be the cause of blindsight connec...
ConclusionData from this large, long-term study indicate that the nature, character, and frequency of SAEs in real-world settings are consistent with natalizumab's known safety profile. (Funded by Biogen; ClinicalTrials.gov identifiers: NCT00477113 and NCT00483847.)
This study examined the impact of psychiatric comorbidity on QOL in patients admitted to two level 4 epilepsy monitoring units (EMUs).MethodsIn this prospective observational study, 200 patients admitted to two level 4 EMUs completed standardized surveys including the Quality of Life in Epilepsy (QOLIE-31-P), Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire (PHQ-9), and Beck Depression Inventory-II (BDI-II). Hierarchal multiple regression was performed to assess impact on QOL.ResultsOf the 200 participants, 113 had a diagnosis of epilepsy, 36 had a diagnosis of PNES, and 51 were excluded for nondia...
This study is in line with previous literature highlighting the difficulty in retrospectively differentiating SE from psychogenic status based on clinical events description recorded in the medical chart.
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Alexia Fasola, F.-Xavier Alario, Marion Tellier, Bernard Giusiano, Carlo Alberto Tassinari, Fabrice Bartolomei, Agnès TrébuchonAbstractPatients suffering from drug-resistant temporal lobe epilepsy show substantial language deficits (i.e., anomia) during their seizures and in the postictal period (postictal aphasia). Verbal impairments observed during the postictal period may be studied to help localizing the epileptogenic zone. These explorations have been essentially based on simple tasks focused on speech, thus disregarding t...
ConclusionPatients and physicians' priorities in the management of epilepsy overlap only in part. Patients are satisfied with their caring physicians and less satisfied with communication and management of routine and emergency problems.
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