A Clinical Model for Identifying an Inflammatory Phenotype in Mood Disorders

Publication date: Available online 10 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Nicole Kramer-Lange, Victoria Cosgrove, Kiley Dunlop, Mehala Subramaniapillai, Roger S. McIntyre, Trisha SuppesAbstractIncreasingly, clinical research has found inflammatory correlates of psychiatric disorders, particularly mood symptomatology. Biological measures may provide greater precision in many cases and may capture clinically-relevant inflammatory signposts, such as central obesity risk, inflammation-associated co-morbid medical conditions, or proinflammatory lifestyle choices. In order to expand understanding of the role of inflammation in mood disorders, we propose a more inclusive clinical model for capturing inflammasome phenotype by identifying clinically-relevant inflammatory phenotypes grounded in biology. Our model includes chronic conditions and lifestyle behaviors associated with clinically elevated inflammation in mood disorders. Elements of this “inflamed depression” model include: obesity, low HDL concentrations, elevated triglyceride concentrations, chronically elevated blood pressure, clinical diagnosis of hypothyroidism, migraines, rheumatoid arthritis, adult onset diabetes, inflammatory bowel diseases, inflammatory skin conditions, and lifestyle factors including smoking cigarettes and chronic stress.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research