The cartonectin levels at different stages of chronic kidney disease and related factors.

The cartonectin levels at different stages of chronic kidney disease and related factors. Ren Fail. 2019 Nov;41(1):42-46 Authors: Yavuz YC, Altınkaynak K, Sevinc C, Ozbek Sebin S, Baydar I Abstract INTRODUCTION: Cartonectin was defined as a new adipokine released from rat and human adipocyte tissues, which is also known as CORS 26 or CTRP3 protein. Although there are several studies investigating the effects of cartonectin with obesity, anti-inflammatory mechanisms, and cardioprotective effects, there is no study about the effects of cartonectin in patients with chronic kidney disease yet. We aimed to investigate cartonectin levels in predialysis and dialysis patient groups, in other words, at different stages of chronic kidney disease, by comparing with the control group. In addition, we aimed to discuss the probable causes of the differences between the patient groups that would be determined, together with the factors that might be effective. METHODS: A total of 150 patients, including 47 hemodialysis patients, 73 predialysis CKD patients, and 30 healthy individuals were enrolled in the study. Serum cartonectin levels were determined by using enzyme-linked immunosorbent assay (ELISA) method. FINDINGS: Serum cartonectin levels were found to be significantly higher in the hemodialysis patient group compared to predialysis group and healthy individuals (p 
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research

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The epidemic of obesity parallels that of chronic kidney disease (CKD). Obesity worsens the course of CKD mainly defined by an abnormal glomerular filtration rate (GFR). Patients with severe obesity stages (II and III with body mass index, BMI>35 kg/m2) are eligible for bariatric surgery (BS), which is the most efficient method of achieving durable weight loss. BS may reverse glomerular hyperfiltration, albuminuria, improve adipocytokine profile, and relieve diabetes and hypertension. Obesity remission following BS might prevent the progression of renal failure in populations with morbid obesity.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
The epidemic of obesity parallels that of chronic kidney disease (CKD). Obesity worsens the course of CKD, mainly defined by an abnormal glomerular filtration rate (GFR). Patients with severe obesity stages (II and III with body mass index>35 kg/m2) are eligible for bariatric surgery (BS), which is the most efficient method of achieving durable weight loss. BS may reverse glomerular hyperfiltration and albuminuria, improve adipocytokine profile, and relieve diabetes and hypertension. Obesity remission after BS might prevent the progression of renal failure in populations with morbid obesity.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Controversies in Bariatric Surgery Source Type: research
Chronic kidney disease (CKD) affects a substantial minority of people with type 2 diabetes (T2D). Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed Stage 3 or worse disease (estimated glomerular filtration rate [eGFR]
Source: Journal of Diabetes - Category: Endocrinology Authors: Tags: Editorial Source Type: research
Population of patients with the impaired kidney function grows around the world. With the advances of the contemporary medicine people live to the older age, survive cardiac and cerebrovascular events, recover from the complex surgeries, overcome malignancies, infections and autoimmune diseases. That all frequently leads to the development of variable degree of chronic kidney impairment in form of interstitial and/or glomerular injury. Patients with chronic kidney disease (CKD) often share risk factors of hypertension, poorly controlled diabetes mellitus, arterial and venous vascular disease, obesity, malnutrition and chro...
Source: Journal of the American College of Certified Wound Specialists - Category: Dermatology Authors: Source Type: research
Sodium excretion and associated factors in urine samples of African descendants in Alcântara, Brazil: a population based study. Ren Fail. 2018 Nov;40(1):22-29 Authors: Dos Santos EM, Brito DJA, Calado IL, França AKT, Lages JS, Monteiro Junior FDC, Dos Santos AM, Salgado Filho N Abstract In most countries, salt intake has been excessive and constitutes one of the main risk factors for disease development, especially hypertension. Factors such as age, gender, sedentary lifestyle, smoking, African descent, obesity, dietary habits and family history of hypertension may be associated with high ...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Suboptimal fluid intake may require enhanced release of antidiuretic hormone (ADH) or vasopressin for the maintenance of adequate hydration. Enhanced copeptin levels (reflecting enhanced vasopressin levels) in 25% of the common population are associated with enhanced risk of metabolic syndrome with abdominal obesity, type 2 diabetes, hypertension, coronary artery disease, heart failure, vascular dementia, cognitive impairment, microalbuminuria, chronic kidney disease, inflammatory bowel disease, cancer, and premature mortality. Vasopressin stimulates the release of glucocorticoids which in turn up-regulate the serum- and g...
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
ABSTRACT AimsTo characterize the incidence of diabetes‐associated complications and assess the safety of sitagliptin in participants with chronic kidney disease (CKD) in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). Materials and methodsFor participants with baseline eGFR measurements (n = 14,528), baseline characteristics and safety outcomes were compared for the CKD cohort (eGFR
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Previous Prevention of CAD Prevention is classified into primordial, primary and secondary. Primordial prevention is community level intervention to reduce risk factors and mostly not under the purview of the individual physician. Primary prevention is by controlling the risk factors. Non modifiable risk factors for CAD Age, gender, race/ethnicity and genetic predisposition or family history are considered the non modifiable risk factors for CAD. Prevalence of CAD increases as age advances and it is definitely more common in males. A strongly positive family history of premature coronary artery disease increases the r...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
In conclusion, dulaglutide treatment of clinical trial participants with T2D did not affect eGFR and slightly decreased albuminuria.
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: BRIEF REPORT Source Type: research
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