Radiosensitivity: Gender and Order of Administration of G-CSF, An Experimental Study in Mice.

In conclusion, these findings indicate that male mice are more sensitive to TBI than females. Filgrastim improved survival in both genders irrespective of whether given pre- or postirradiation, but in males the improvement was significantly less if an injection was given before irradiation. These results suggest that, to prevent toxicity most effectively, G-CSF should not be given before cytotoxic therapy. While a completely different experimental model was used here, these results may also be extrapolated to indicate that endocrine cell-cycle suppression therapy should not be given before or during cytotoxic therapy of hormone-dependent tumors (e.g., breast and prostate cancer), thus a reduction in the efficacy of cell-cycle-dependent therapy can be prevented.
PMID: 30730283 [PubMed - as supplied by publisher]

Source: Radiation Research - February 7, 2019 Category: Physics Authors: Hultborn R, Albertsson P, Ottosson S, Warnhammar E, Palm Å, Palm S, Elmroth K Tags: Radiat Res Source Type: research