Theoretical investigation of design space for multi layer drug eluting bioresorbable suture threads.

Theoretical investigation of design space for multi layer drug eluting bioresorbable suture threads. Curr Pharm Biotechnol. 2019 Feb 06;: Authors: Casalini T, Rossi F, Brizielli L, Perale G Abstract The here presented work is focused on the development of a comprehensive model for the description of drug release from a double - layer bioresorbable suture thread and the therapeutic efficacy of the active compounds delivered in the surrounding tissue. In particular, the system under investigation is composed by a core of slow-degrading poly-lactic-acid-co-ε-caprolactone (PLCL), where an antibiotic compound (Vancomycin) is loaded, surrounded by a shell of a fast-degrading polylactic-co-glycolic acid (PLGA) which contains an anesthetic drug (Lidocaine hydrochloride) for the post-surgical pain relief. This system is of potential interest for the combined effects provided by the different active molecules, but the different release and polymer degradation dynamics, as well as their mutual influence, do not allow an intuitive a priori evualuation of device behavior, which can be rationalized through mathematical modeling. The model takes into account the main involved phenomena (polymer degradation and diffusion of the drugs within the device and the tissue, where they are metabolized) and their synergic effects on the overall system behavior. Model results are discussed in order to quantify the impact of the main design parameters on devi...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research