Combinatorial inhibition of mTORC2 and Hsp90 leads to a distinctly effective therapeutic strategy in malignant pheochromocytom.

CONCLUSIONS: Our results demonstrated that combinatorial inhibition of mTORC2 and Hsp90 could increase their antitumor effect and destabilize Akt signaling in PC12 cells, suggesting combinatorial inhibition of both mTORC2 and Hsp90 might be an effective therapeutic strategy for mPCC. PMID: 30727894 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30727894?dopt=Abstract

Source: Current Cancer Drug Targets - February 6, 2019 Category: Cancer & Oncology Authors: Zhang X, Gao F, Zhong S Tags: Curr Cancer Drug Targets Source Type: research

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