Renalase regulates peripheral and central dopaminergic activities.

RENALASE REGULATES PERIPHERAL AND CENTRAL DOPAMINERGIC ACTIVITIES. Am J Physiol Renal Physiol. 2014 Nov 19;:ajprenal.00274.2014 Authors: Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M Abstract Renalase is a recently identified FAD/NADH-dependent amine oxidase mainly expressed in kidney, which is secreted into blood and urine where it was suggested to metabolize catecholamines. The present study evaluated central and peripheral dopaminergic activities in the renalase knockout (KO) mouse model and examined the changes induced by recombinant renalase (RR) administration on plasma and urine catecholamines levels. Compared to wild type (WT) mice, KO mice presented increased plasma levels of epinhephrine (EPI), norepinephrine (NE) and DA which were accompanied by increases in the urinary excretion of EPI, NE, DA. In addition, the KO mice presented an increase in urinary DA/L-3,4-dihydroxyphenylalanine (L-DOPA) ratios without changes in renal tubular aromatic-L-amino acid decarboxylase activity. By contrast, the in vivo administration of RR (1.5mg/kg, s.c.) to KO mice was accompanied by significant decreases in plasma levels of EPI, DA and L-DOPA as well as in urinary excretion of EPI, DA and DA/L-DOPA ratios notwithstanding the accompanied increase in renal AADC activity. In addition, the increase in renal DA output observed in renalase KO mice ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research