The management of Osteogenesis Imperfecta in Adults: state of the art

Publication date: Available online 8 February 2019Source: Joint Bone SpineAuthor(s): Marie-Hélène Lafage-Proust, Isabelle CourtoisABSTRACTOsteogenesis imperfecta (OI) is a genetic disease whose clinical phenotype and severity vary considerably. The increased risk of fractures due to bone fragility persists in adulthood, notably after 40 years of age, albeit at a lower level than during growth. Adults with OI require periodic evaluations of the other manifestations of OI including hearing loss, respiratory impairments, ocular and dental abnormalities, and cardiovascular disease. Follow-up should therefore be provided by a multidisciplinary team, at intervals tailored to disease severity. Currently used treatments for OI have not been proven to decrease the fracture risk but are consistently effective in increasing bone mineral density. Specific orthopedic expertise is often required to treat fractures in patients with OI. A combination of periodic evaluations, chronic pain control, and disability management is necessary to improve quality of life.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

Related Links:

ConclusionAvailable data suggest that the information needs of people with low back pain are centred around their desire for a diagnosis, potentially contributing to expectations for and overuse of imaging. People with low back pain expressed a strong desire for clear, consistent and personalised information on prognosis, treatment options and self-management strategies, related to healthcare and occupational issues. To correct unhelpful beliefs and optimise delivery of evidence-based therapy, patient and healthcare professional education (potentially by an integrated public health approach) may be warranted.
Source: Journal of Physiotherapy - Category: Physiotherapy Source Type: research
Authors: Schweighardt AE, Juba KM Abstract Acetaminophen is among the most commonly used nonopioid analgesics, but significant variation exists in its prescribing practices for cirrhosis patients. Our primary objective was to describe the quality of evidence supporting or refuting the use of acetaminophen in patients with hepatic dysfunction. A comprehensive literature review of PubMed, Cochrane Library, Web of Science, and International Pharmaceutical Abstracts using the search terms "acetaminophen," "paracetamol," "chronic liver disease," "cirrhosis," and "hepatic dise...
Source: Journal of Pain and Palliative Care Pharmacotherapy - Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research
Abstract The present study explores the longitudinal development between Grade 3 word level reading skills and higher level semantic skills to Grade 10 reading comprehension for 3,157 students. In particular, this work focused on how the developmental relations varied for subsamples of students who are English learners (EL; N = 308), students identified as specific learning disability (SLD; N = 133), and general education (Gen Ed; N = 2,716) students who have no formal classification or diagnoses. Multiple group structural equation modeling showed that the relation between Grade 3 vocabulary and Grade 10 reading c...
Source: Journal of Learning Disabilities - Category: Disability Authors: Tags: J Learn Disabil Source Type: research
Publication date: September 2019Source: Urology Case Reports, Volume 26Author(s): Eriawan Agung Nugroho, Dila Junita, Yanuar Hendra WijayaAbstractGiant bladder stone more than 100 g is a rare finding and commonly associated with urinary tract infection. 32-year-old male came with history of lower abdominal pain, dysuria for 2 years. Patient had history of recurrence urinary tract infections for past 1 year and also complaint pollakiuria, incomplete emptying and hematuria. Abdominal radiograph and ultrasound revealed round calcified pelvic calculi. Patient received antibiotic and underwent open cystolithotomy. Extirpated ...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
It is estimated that comorbidity between depression and chronic pain reaches more than half of the depressed adult patients around the world. Evidence indicates that some stressors, such as early-life stress (ELS), mediate the co-occurrence of depression a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Civil plaintiffs often seek compensation for their psychological injuries. Yet little is known about jurors' preconceived notions (or schemas) for a prospective plaintiff's pain and suffering. The present studies examined (a) whether jurors have psychologi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
BACKGROUND: Road traffic injuries disproportionately affect low- and middle-income countries (LMICs) and are associated with femur fractures that lead to long-term disability. Information about these injuries is crucial for appropriate healthcare resource ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
INTRODUCTION: Upper extremity pain among manual wheelchair users induces functional decline and reduces quality of life. Research has identified chronic overuse due to wheelchair propulsion as one of the factors associated with upper limb injuries. Lack of...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Go Baby Go is a program at the University of Delaware that adapts ride-on toy cars for the recreation of children with disabilities. Colombia's health-care system faces many challenges in delivering early mobility devices to these children; thus, here (in ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
BACKGROUND: Alcohol is one of the leading causes of death and disability worldwide. Rates of alcohol abuse in Moshi, Tanzania, are about 2.5 times higher than the Tanzanian average. We sought to qualitatively assess the perceptions of alcohol use among inj...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
More News: Back Pain | Cardiology | Cardiovascular | Chronic Pain | Disability | Genetics | Heart | Orthopaedics | Osteogenesis Imperfecta (brittle bone disease) | Pain | Pain Management | Respiratory Medicine