Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A.

CONCLUSION: It seems that TNFα rs1800629 G> A polymorphism decreased the risk of inhibitor formation in Iranian patients with HA. PMID: 30727925 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

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Authors: Hart DP, Kessler CM, Aledort L Abstract Hemophilia therapeutics are evolving rapidly. Comprehensive care must also evolve to embrace this change. Online tools and guidelines are widely available to optimize prophylaxis with conventional clotting factor concentrates using an individual's predicted pharmacokinetic profile. Novel hemostatic agents (e.g. biphenotypic antibody) are also becoming widely available, with other agents with differing mechanisms of action in final stages of trial. Contemporary issues including challenges of prophylaxis; bleed treatment; laboratory monitoring and inhibitor risk/survei...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Condition:   Factor VIII Deficiency Intervention:   Drug: BIVV001 Sponsor:   Sanofi Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract A sensitive and selective electrochemical method for simultaneous detection of two hemophilia A-related microRNAs (miR-1246 and miR-4521) was developed. This detection tactic was based on gold nanoparticles (AuNPs), heavy metals quantum dots-encapsulated metal-organic frameworks (QDs@ZIF-8), and catalytic hairpin assembly (CHA) for signal application. Primarily, hairpins H1 and H2 were hybridized with targets miR-1246 (T1) and miR-4521 (T2) for forming H1-T1 and H2-T2 duplex stranded DNAs (dsDNAs) that were able to open the hairpins H3 and H4 for the formation of H1-H3 and H2-H4 dsDNAs. Meanwhile, lots of...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
ConclusionsTotal knee arthroplasty has good outcome with respect to clinical as well as functional outcome in haemophilic arthropathy. Although the results and outcome of total knee arthroplasty in haemophilic knee arthropathy may still be inferior to the results seen in a normal individual, a multidisciplinary approach yields a better functional and quality of living in such haemophilic patients.
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Condition:   Hemophilia A Intervention:   Biological: ADYNOVI/ADYNOVATE Sponsors:   Baxalta now part of Shire;   Baxalta Innovations GmbH, now part of Shire;   Shire is now part of Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Mild Hereditary Factor VIII Deficiency Disease Without Inhibitor;   Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor;   Hemophilia A Intervention:   Drug: Emicizumab Sponsor:   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Hemophilia A Intervention:   Biological: ADYNOVI/ADYNOVATE Sponsors:   Baxalta now part of Shire;   Baxalta Innovations GmbH, now part of Shire;   Shire is now part of Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Mild Hereditary Factor VIII Deficiency Disease Without Inhibitor;   Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor;   Hemophilia A Intervention:   Drug: Emicizumab Sponsor:   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS:  Within the last decade more patients with severe haemophilia were switched to a prophylactic regimen going along with a moderate increase in factor consumption achieving a low ABR and AJBR. PMID: 31711245 [PubMed - as supplied by publisher]
Source: Hamostaseologie - Category: Hematology Authors: Tags: Hamostaseologie Source Type: research
Source: Cardiovascular and Haematological Disorders - Drug Targets - Category: Cardiology Authors: Tags: Research article Source Type: research
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