Survivorship and Functional Outcomes of Cementless versus Cemented Total Knee Arthroplasty: A Meta-Analysis

J Knee Surg DOI: 10.1055/s-0039-1678525The purpose of this meta-analysis was to assess the evidence supporting the use of cementless versus cemented total knee arthroplasties (TKAs). Specifically, we evaluated (1) all-cause survivorship, (2) aseptic survivorship, and (3) functional outcomes (Knee Society Scores [KSS], Oxford Knee Scores, Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] scores, and ranges of motion [ROMs]). A literature search was performed for studies that evaluated cementless versus cemented TKAs published between 2000 and 2017. Selected studies included three randomized controlled trials, three retrospective observational studies, and one prospective observational study that met the following criteria: (1) primary TKAs, (2) compared cementless and cemented TKAs, (3) implant survivorship that described the causes of failure, and (4) at least one functional outcome. To compare the two cohorts, pooled odds ratios (OR) and 95% confidence intervals (95% CI) were used to calculate tibial and femoral implant survivorship, and pooled mean differences (MD) and 95% CI calculated the functional scores and ROMs. Based on pooled data from the few number of studies, cementless TKAs had a better all-cause survivorship (OR = 0.37; 95% CI, 0.15–0.92) and tended to have a better aseptic survivorship (OR = 0.44; 95% CI, 0.17–1.14). However, this is likely due to the 83.3% weight of the single cementless study poten...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

Related Links:

BMPs, TGFβ, and border security at the interzone. Curr Top Dev Biol. 2019;133:153-170 Authors: Lyons KM, Rosen V Abstract Synovial joints enable movement and protect the integrity of the articular cartilage. Joints form within skeletal condensations destined to undergo chondrogenesis. The suppression of this chondrogenic program in the interzone is the first morphological sign of joint formation. While we have a fairly good understanding of the essential roles of BMP and TGFβ family members in promoting chondrogenic differentiation in developing skeletal elements, we know very little about h...
Source: Current Topics in Developmental Biology - Category: Biology Authors: Tags: Curr Top Dev Biol Source Type: research
Condition:   Knee Osteoarthritis Interventions:   Drug: Biofreeze;   Drug: Placebo Sponsor:   Sport and Spine Rehab Clinical Research Foundation Terminated
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Complex Regional Pain Syndromes;   Fibromyalgia;   Stroke;   Traumatic Brain Injury;   Osteoarthritis;   Back Pain;   Sciatica Intervention:   Device: Virtual Environment Biofeedback Sponsor:   Cambridge University Hospitals NHS Foundation Trust Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The objectives of the present narrative review were to identify, summarize, and cluster all the potentially modifiable risk factors that influence the course of KOA, and discuss their susceptibility to alteration via personal, clinical, and public strategy. For this purpose, Pubmed and Scopus databases were queried using the terms “knee osteoarthritis”, “risk factors” and “improvement”. Six main categories of modifiable risk factors were identified: (1) obesity and overweight, (2) comorbidity, (3) occupational factors, (4) physical activity, (5) biomechanical factors, (6) dietary exposur...
Source: Rheumatology International - Category: Rheumatology Source Type: research
This study compared ESWT, Wharton's jelly mesenchymal stem cells (WJMSCs) and combination of ESWT and WJMSCs therapies for early OA of the rat knee. The results showed ESWT, WJMSCs and combination of therapies significantly improved early OA knee based on analysis of pathological findings, micro-CT and immunohistochemistry (IHC) stain. The combined therapy group increased the bone volume (61.755 ± 1.537), and trabecular thickness (0.215 ± 0.014; P
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Li L, Yang X, Yang L, Zhang K, Shi J, Zhu L, Liang H, Wang X, Jiang Q Abstract The purpose of this study was to determine the effect of the degenerative medial meniscus and traumatic lesions on the biomechanical behavior of the knee. An elaborate three-dimensional (3D) finite element model of the total knee joint containing bones, articular cartilages, main ligaments, and menisci was developed from a combination of magnetic resonance images and computed tomography. Three types of meniscus tears were employed to represent the degenerative and traumatic lesions. The stress and meniscus extrusion of healthy a...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Publication date: Available online 23 March 2019Source: Journal of OrthopaedicsAuthor(s): Hideki Warashina, MichianaKato, Shinji Kitamura, Taiki Kusano, Yukiharu Hasegawa
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
CONCLUSION: LncRNA H19 aggravated the injury of LPS-induced C28/I2 cells by sponging miR-130a, hinting a novel regulatory mechanism and a potential therapeutic target for OA. PMID: 30900425 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
This study shows promise for viscosupplementation with NASHA in the treatment of ankle OA. A single injection was associated with clinically meaningful reductions in pain and disability during a 26-week period and, in general, was well tolerated.
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 22 March 2019Source: Joint Bone SpineAuthor(s): Murielle Michel, Joséphine Bryère, Milka Maravic, Christian MarcelliAbstractObjectives:Temporal and geographic variations in knee osteoarthritis (OA) incidence occur worldwide. Regional variations also exist for socioeconomic status. We analyzed the association between socioeconomic deprivation (SED) and knee replacement (KR) incidence and assessed the proportion of KR associated with affluence.Methods:Patients aged 15 years and over hospitalized for KR in 2013 were included. We linked each patient to a municipality of residenc...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
More News: Osteoarthritis | Study | Universities