Metronidazole induced cerebellar dysfunction: A dose related phenomenon or a pharmacogenetic outcome?

Metronidazole induced cerebellar dysfunction: A dose related phenomenon or a pharmacogenetic outcome? Curr Drug Saf. 2019 Feb 06;: Authors: Kaur U, Kumar I, Singh A, Kumar M, Chakrabarti SS Abstract Metronidazole, a widely used antibacterial and antiprotozoal drug, is often the drug of choice in amoebic liver abscess. The drug, otherwise safe, can cause serious central nervous disturbances in rare circumstances. Here we report a case of cerebellar dysfunction in the form of slurring of speech and episodes of falls, in an elderly male following a three-week course of metronidazole therapy. The patient manifested classic radiologic features of metronidazole neurotoxicity. Marked improvement in clinical symptoms were seen following drug discontinuation. PMID: 30727914 [PubMed - as supplied by publisher]
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research