Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats

Publication date: Available online 7 February 2019Source: Life SciencesAuthor(s): Hossein Shateri, Akram Ranjbar, Nejat Kheiripour, Hassan Ghasemi, Yasin Pourfarjam, Elahe Habibitabar, Hamid Gholami, Heresh MoridiAbstractAimsOxidative stress induced by diabetes mellitus (DM) is considered as one of the main causes of infertility in diabetic patients. The aim of the present study was to assess the effect of Tempol – as a synthetic antioxidant- on the testis oxidative stress and sperm parameters in type 2 diabetic (T2D) rats.Main methodsTwenty male Wistar rats were divided into 4 groups. Control groups (C) and diabetic groups (D); the control and diabetic groups received Tempol (100 mg/kg) for one month. Sperm parameters and oxidative stress biomarkers were evaluated in testicular tissue.Key findingsThe results demonstrated that administration of Tempol in diabetic rats improved sperm motility and viability and decreased the count of abnormal sperms. Also Tempol decreased the fasting blood sugar (FBS) and lipid peroxidation (LPO). In addition, Tempol significantly increased total antioxidant capacity (TAC) levels in testis tissue of T2D rats. Histopathological changes were also improved in the diabetic treated group.SignificanceTaken together, the results indicated that Tempol improved fertility parameters in a diabetic rat through reducing oxidative stress.
Source: Life Sciences - Category: Biology Source Type: research