Functional RNA Modifications Environment and Disease (FRAMED) (R21 Clinical Trial Not Allowed)

Funding Opportunity RFA-ES-19-002 from the NIH Guide for Grants and Contracts. Chemical modifications of proteins, DNA and RNA nucleoside moieties play critical roles in regulating gene expression. Emerging evidence suggests these RNA modifications (epitranscriptomics) have substantive roles in basic biological processes. Recent studies in yeast, Drosophila and rodent models demonstrate stressors can induce RNA modifications, with specific epitranscriptomic reprogramming of some regulatory RNAs. The purpose of the eFRAMED FOA is to solicit and support R21 applications that propose conducting innovative, high risk, high reward research to enhance our understanding of how environmental exposures impact this layer of cellular regulation.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding