Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma

ConclusionsThese findings suggest the potential usefulness of THC and its combination with NQO1 inhibitor as a therapeutic option for ESCC.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research

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We report 2 elderly female patients with LPE who developed squamous cell carcinoma (SCC). Both underwent laparoscopic ischemic gastric preconditioning followed 2 weeks later by 3-field esophagectomy. Final pathological stages were carcinoma-in-situ and pT3N2, respectively. No adjuvant therapy was given. The patient with in-situ cancer has no evidence of recurrence at 24 months. The 2nd patient opted to follow up locally and died 8 months later. LPE should be closely monitored for malignant degeneration. Esophagectomy should be considered when malignancy is detected.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusion: SEMS effectively reduced dysphagia in inoperable esophageal cancer. Better survival rates were observed in females than males.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
CONCLUSIONS: The level of serum microRNA-1290 in ESCC patients increased significantly, and its expression level could reflect the progress of ESCC, suggesting that serum microRNA-1290 might be a useful diagnostic and prognostic marker of ESCC. PMID: 31306104 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
This article summarizes the milestones in the development of camrelizumab leading to this first approval for classical Hodgkin lymphoma.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Conclusions: Our results demonstrate that miR-216a-5p might serve as a tumor suppressor in ESCC cells through negatively regulating TCTN1 expression, indicating the possibility that miR-216a-5p and TCTN1 might be attractive targets for ESCC therapeutic intervention. PMID: 31297133 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Cell Mol Biol Lett Source Type: research
Publication date: Available online 12 July 2019Source: Pathology - Research and PracticeAuthor(s): Mingzhu Zong, Yan Liu, Kai Zhang, Yi J, Longbang ChenAbstractIncreasing evidence indicates that microRNAs may play important roles in tumor development and may take part in different processes in different cancers. miR-429 is known as a cancer suppressor or oncogene that is dysregulated in different malignancies, including esophageal squamous cell carcinoma (ESCC). However, the effect of miR-429 in ESCC has not been fully explored. The purpose of this study was to investigate the functions of miR-429 in ESCC. qRT-PCR assays w...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Esophageal cancer (EC) is considered a most common gastrointestinal malignant cancer in our world (1). It has a highly morbidity and mortality, more than 450,000 new cases of EC were diagnosed, and about 400,000 patients were died in each year (2). According to histological type, EC was classified two different forms, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) (3). Several reports revealed that ESCC is the main histological subtype of EC in developing countries (4).
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research
Publication date: Available online 11 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Brandon C. Chapman, Michael Weyant, Sarah Hilton, Patrick W. Hosokawa, Martin D. McCarter, Ana Gleisner, Nader D. Nader, Csaba GajdosAbstractBackgroundEsophageal squamous cell carcinoma (ESCC) has been poorly studied, approached with therapeutic nihilism and likely undertreated. We studied the impact of clinical and patient factors on the survival of ESCC in the US.MethodsWe selected patients with Stage I-III ESCC from 2004 to 2013 using the National Cancer Database (NCDB). Patients were categorized into the following treatment ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Qiao Y, Chen C, Yue J, Yu Z Abstract OBJECTIVE: The aim of this study was to evaluate the prognostic value of a novel tumor marker index (TMI) based on preoperative serum levels of squamous cell carcinoma antigen (SCC) and cytokeratin 19 fragment (CYFRA 21-1) for patients with resectable esophageal squamous cell carcinoma (ESCC). METHODS: A total of 315 ESCC patients who had underwent curative surgery between 2008 and 2012 were retrospectively included in this study. The TMI was defined as the geometric mean of normalized SCC and CYFRA21-1 levels. Univariate and multivariate survival analyses were perf...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) t...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
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