Clustering of Cardiovascular Risk Factors and Diabetes: A Prospective Cohort Study on the Inner Mongolian Population in China

ConclusionThe clustering of CVRFs increased the risk of T2DM. On the basis of fast heart rate, the cluster of abdominal obesity and other CVRFs had higher predictive value for T2DM than the other three CVRF clusters.
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research

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ConclusionOur study demonstrated that if standardized indicators are investigated in population-based samples, the effectiveness of T2DM care can be monitored by ad hoc surveys. The systematic application of this approach completed with the detailed documentation of the applied therapies could demonstrate the public health impact of certain modifications in T2DM care. An overall improvement in metabolic control (glycaemic control, lipid status and obesity) was observed, which was not accompanied by improved therapeutic target achievement for systolic blood pressure.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
Conclusions/interpretationMEDI4166 was associated with an acceptable tolerability profile and significantly decreased LDL-cholesterol levels in a dose-dependent manner in overweight or obese patients with type 2 diabetes. However, there were no significant reductions in postprandial glucose levels at any dose of MEDI4166.Trial registrationClinicalTrials.gov NCT02524782FundingThis study was funded by MedImmune LLC, Gaithersburg, MD, USA.
Source: Diabetologia - Category: Endocrinology Source Type: research
In this study, we performed a transversal investigation on 100 patients with diabetes type 2 and 10 controls with no clinical history of diabetes. A questionnaire was developed with the anthropometric data and biochemical following values: fasting blood glucose (GLU), total cholesterol (TCHOL), triglycerides (TRG), high-density lipoproteins (HDL-C) and glycosylated hemoglobin (GHbA1c) and calculated levels of low-density lipoprotein (LDL-C). We describe further the characteristics of lipid parameters in the study population. To this end, we analyzed the data using descriptive statistics by mean and standard deviation.Accor...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionThere are conflicting results about the effect of SGLT2 inhibitors on the lipid profile in the literature. According to our data, dapagliflozin has positive effects on lipid profile as weight and glycemic control and it is well tolerated. Therefore, dapagliflozin therapy is beneficial because of the positive change in lipid profile and weight loss in diabetic patients with overweight and hyperlipidemia.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Your Society are delighted to announce that we have awarded 10 Early Career Grants of£10,000 to early career members, to help fund their exciting and cutting edge research projects. Mr James Nicholson - Defining the early response to oncogenic Braf in pituitary progenitor/stem cells.Miss Emma McGlone - Statins and type 2 diabetes mellitus: is glucagon the missing link?Dr Nikolaos Nikolaou- Hepatic 5β-reductase (AKR1D1) activity as a regulator of adipose tissue biology and function; exploring theliver-adipose endocrine axis.Dr Nan Li - A novel animal model to explore the role of sex steroids on sex different...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
CONCLUSIONS: This variant of the APOA1 gene showed important effects on HDL-cholesterol, HOMA-IR and insulin resistance after DBP for 3 years. PMID: 30556889 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ConclusionLSG has a significant effect on patients with type 2 diabetes mellitus whose BMI less than 30  kg/m2 in a short time, but its long-term effectiveness needs to be further followed up.
Source: Obesity Surgery - Category: Surgery Source Type: research
CONCLUSIONS: Twelve-week pegbelfermin treatment did not impact HbA1c concentrations, but QW and higher daily doses were associated with improved metabolic parameters and fibrosis biomarkers in patients with obesity and T2DM predisposed to fatty liver. These results support evaluation of pegbelfermin in patients with obesity-related metabolic diseases (e.g., nonalcoholic steatohepatitis). PMID: 30520566 [PubMed - as supplied by publisher]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
BackgroundThe treatment status of type 2 diabetes mellitus (T2DM) in Ningbo has not been reported in the past. To evaluate the current status of T2DM in Ningbo and provide evidence to formulate more policies, a multicenter investigation was needed.MethodsThe Ningbo Clinical Research Group of Diabetes constituted nine hospitals. Participants included 3015 patients who visited the nine hospitals from June to December 2016. General characteristics, the medication situation, the laboratory indexes in nearly 3  months consisting of glycosylated hemoglobin level (HbA1c), low‐density lipoprotein cholesterol (LDL‐C), and ...
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Tags: RESEARCH ARTICLE Source Type: research
The objective of this study was to determine the prevalence and the factors associated with non-alcoholic fatty liver disease (NAFLD) among type-2 diabetes mellitus (T2DM) patients in Abha City, Southwestern Saudi Arabia. Using a cross-sectional study design, a representative sample of 245 T2DM patients were recruited from all primary healthcare centers in Abha city. A detailed medical history as well as laboratory investigations were done. NAFLD was diagnosed using abdominal ultrasound examination. The overall prevalence of NAFLD was 72.8% (95% CI: 66.6%–78.1%). In a multivariable regression analysis, the risk o...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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