Effect of human embryonic morphological development on fetal growth parameters: the Rotterdam Periconceptional Cohort (Predict Study)

Publication date: Available online 21 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Francesca Parisi, Melek Rousian, Anton H.J. Koning, Sten P. Willemsen, Eric A.P. Steegers, Régine P.M. Steegers-TheunissenAbstractResearch questionIs embryonic morphological development according to the Carnegie stages associated with pregnancy outcome?DesignIn a tertiary hospital-based cohort, 182 singleton non-malformed pregnancies were selected. Serial transvaginal three-dimensional ultrasound (3D-US) scans were carried out between 6+0 and 10+2 gestational weeks. Embryonic development was annotated according to the morphological criteria of the Carnegie classification using a virtual reality system. Second-trimester biparietal diameter, head circumference, abdominal circumference and femur length measurements were retrieved from medical records. Z-scores were calculated for mid-pregnancy estimated fetal weight (EFW) and newborn birth weight. Associations between longitudinal Carnegie stages and fetal growth parameters were investigated using linear mixed models, with subgroup analysis based on fetal gender.ResultsA total of 576 first-trimester 3D-US scans were analysed (median of three scans per pregnancy). Embryonic development was positively associated with EFW z-score (β = 0.69; 95% CI 0.51 to 0.86; P
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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ConclusionsWe present data from 35 cases of exome sequencing applied in a setting of fetal malformations. Importantly, though, we wish to share our personal experiences with implementing WES into a prenatal setting. As a medical society, we must continue to share what we do not understand, what went wrong, what is difficult, and what we do not agree upon. A common understanding and language are warranted. We also advocate that more research is needed concerning the clinical value, as well as costs and patient perspectives, of using WES in pregnancy. We believe that WES will lead to improved prenatal and perinatal care.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
ConclusionsWith an indication of advanced maternal age but normal ultrasound scans, the prevalence of pathogenic CNVs was 0.4% and that of susceptibility CNV 0.7%. As CNVs are independent of maternal age, the prevalence is likely the same for younger women. Thus, this study provides further evidence that chromosomal microarray analysis should be available for all women who wish to receive diagnostic testing, as this risk is above the cut ‐off of 1:300 for Down syndrome, leading to the suggestion of invasive testing. A chromosomal microarray analysis based on SNP‐array platform is preferable, as it can also detect unipa...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
ConclusionThe effect of HG on fetal development as expressed by variations in fetal movement profiles in this pilot study suggest that prenatal effects of HG can be measured using movement profiles. Isotope analysis of hair can supplement this with information on nutritional imbalances early in pregnancy.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
AbstractBackgroundWhite matter is responsible for inter-neuronal connections throughout the brain that are a driving force in cognitive development. Diffusion tensor imaging (DTI) fiber tractography has been used to evaluate white matter development in the fetal brain; however, longitudinal studies of DTI fiber tractography to assess white matter development in the third trimester are lacking.ObjectiveTo characterize in utero longitudinal changes in the fetal brain DTI fiber tracts of normal third-trimester fetuses.Materials and methodsFor this single-center prospective longitudinal observational pilot study, we recruited ...
Source: Pediatric Radiology - Category: Radiology Source Type: research
Diagnostic accuracy of first-trimester combined screening for early-onset and preterm preeclampsia at 8-10 weeks compared to 11-13 weeks gestation. Ultrasound Obstet Gynecol. 2020 May 10;: Authors: Mendoza M, Garcia-Manau P, Arévalo S, Avilés M, Serrano B, Sánchez-Durán MÁ, Garcia-Ruiz I, Bonacina E, Carreras E Abstract OBJECTIVES: To compare the capacity of the first-trimester combined screening for preeclampsia (PE) to predict early-onset and preterm PE when biomarkers were assessed before or after 11 weeks of gestation. METHODS: This pros...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
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ConclusionsWith an indication of advanced maternal age but normal ultrasound scans the prevalence of pathogenic CNVs was 0.4% and that of susceptibility CNV 0.8%, respectively. As CNVs are independent of maternal age the prevalence is likely the same for younger women. Thus, this study provides further evidence that chromosomal microarray analysis should be available for all women who wish to receive diagnostic testing as this risk is above the cut ‐off of 1:300 for Down syndrome, leading to the suggestion of invasive testing. A chromosomal microarray analysis based on SNP‐array platform is preferable as it can also de...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
This article is protected by copyright. All rights reserved. PMID: 32337795 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
ConclusionsThe uterocervical angle, measured mid ‐trimester, is a poor predictor of spontaneous preterm birth.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
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