Icariin inhibits chondrocyte apoptosis and angiogenesis by regulating the TDP ‐43 signaling pathway

This study focused on the mechanisms where icariin inhibited chondrocyte apoptosis and angiogenesis by regulating the TDP ‐43 signaling pathway.MethodsA rat osteoarthritis (OA) model was established by collagenase injection. Histological examination of the articular cartilage and synovial tissue was performed 6  weeks after operation. Cartilage cell line overexpressing TDP‐43 and mesenchymal stem cell line (TDP43‐MSCs) of the ratTDP43 gene were established.ResultsIn OA rats transplanted with TDP43 ‐mMSCs, TDP43 was highly expressed in chondrocytes (TDP43‐HC), while TDP43 expression was low in HC and MSCs‐HC (p  
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
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Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
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Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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