Amelanocytic anorectal malignant melanoma—Case report

Publication date: 2019Source: International Journal of Surgery Case Reports, Volume 55Author(s): Marta Serra, Teresa Santos, Margarida Martins, Leonor SardoAbstractIntroductionAnorectal malignant melanoma (AMM), is a rare and aggressive form of melanoma. Accounts for
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research

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Read about this case in which acral lentiginous melanoma was initially diagnosed as a vascular ulcer.Wounds
Source: Medscape Today Headlines - Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news
This study investigated the effect of FBXO22 on melanoma angiogenesis, migration, and invasion. Results showed that FBXO22 staining intensity was increased in malignant melanoma (MM) compared with that in skin tissue (P˂0.001). The percentage of high FBXO22 expression in MM (74.3%) was markedly higher than that in paracancerous and skin tissues (0%) (P˂0.001). FBXO22 was also overexpressed in MM tissues compared with that in normal skin tissues. FBXO22 knockdown in vitro inhibited MM cell migration, invasion, and angiogenesis (P 
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
The overall number of T1 melanomas undergoing nodal biopsy have decreased following the 7th edition of the AJCC Cancer Staging Manual (AJCC 7), according to a new study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
. Beenakker Uveal Melanoma (UM) is the most common primary malignant ocular tumor. The high soft tissue contrast and spatial resolution, and the possibility of generating 3D volumetric and functional images, make Magnetic Resonance Imaging (MRI) a valuable diagnostic imaging technique in UM. Current clinical MRI protocols, however, are not optimized for UM and therefore lack the quality for accurate assessments. We therefore developed a dedicated protocol at a 3 Tesla MRI, using an eye coil, consisting of multi-slice 2D sequences, different isotropic sequences and diffusion and perfusion-weighted images. This protocol ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Liu Y, Kang X, Niu G, He S, Zhang T, Bai Y, Li Y, Hao H, Chen C, Shou Z, Li B Abstract Shikonin, a botanical drug extracted from Lithospermum erythrorhizon, exhibits anti-cancer effects in various cancer cell lines. However, the mechanisms underlying these effects have not been completely elucidated yet. Here, we showed that Shikonin induces apoptosis and autophagy in A375 cells and inhibits their proliferation. Shikonin caused G2/M phase arrest through upregulation of p21 and downregulation of cyclin B1. Shikonin significantly triggered ER stress-mediated apoptosis by upregulating the expression of p-eIF2...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Authors: Paschke L, Jopek K, Szyszka M, Tyczewska M, Malendowicz LK, Rucinski M Abstract Zinc finger protein 91 (ZFP91) gene has been recently acknowledged to possess oncogenic properties. To date, its expression has been examined only in a handful of human organs and cancer types. The aim of the present study was to characterize, for the first time, the ZFP91 expression pattern in a range of human tissues and cancer types. ZFP91 mRNA expression was examined using Cancer Survey cDNA sets. Utilized cDNA samples represented 15 human organs and 17 cancer types. ZFP91 mRNA expression was the highest in the testes and l...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
The objective of the study was to compare efficacy and safety of subcutaneous interferon-α with continuous intravenous IL-2 in Chinese patients with malignant melanoma. A total of 250 patients with unresectable malignant melanoma were subjected to randomized in 1 : 1 ratio. Patients received subcutaneous 9×106 IU/m2 IFN-α (IFN-α group, n=125) or continuous intravenous 9×106 IU/m2 IL-2 (IL-2 group, n=125) at every 21 days for 4 months. The response, progression-free survival, overall survival, adverse effects, and cost were evaluated by experts in the field. IL-2 and...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: CLINICAL REPORTS Source Type: research
No abstract available
Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research
A Ph.D. student has designed a cost-effective and easy-to-use device that can quickly detect cancerous skin cells. Catching cancer earlier can save lives.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news
CONCLUSION: The data revealed a close link between the two methods, supporting the use of the V600E as a primary screen for BRAF mutations in malignant melanoma. Negative results would be recommended for DNA probe testing. V600E antibody is considerably cheaper than the DNA probe assay. The BRAF IHC test can be performed within 24-48 hours, faster than the DNA probe assay enabling patients to receive faster treatment with improved turnaround times. Finally IHC detection is conserving of patient DNA from tumour blocks as only one section is required to perform the assay. PMID: 30870099 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
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