Questions Linger About Steroid Injections and Knee Arthritis Questions Linger About Steroid Injections and Knee Arthritis

A natural history study of knee osteoarthritis suggests that intra-articular steroids might speed joint deterioration.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news

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ConclusionsWithin the limitations of this study, we have failed to identify meaningful bacterial growth in tissues (i.e. condylar head) of the TMJ that would suggest a contributory bacterial pathogenesis for arthritis of the TMJ.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Osteoarthritis (OA) is the most common arthritic condition and a leading cause of pain and disability in people 45 years and older. As the biopsychosocial model of pain hypothesizes that pain is dynamically affected by multidimensional factors, there is a growing interest to understand the biological factors that influence pain among older adults. Beta-endorphin is suggested to be involved in pain sensitivity, but few studies have examined the relationship between beta-endorphin and experimental pain sensitivity in older adults.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Abstract The increase in global lifespan has in turn increased the prevalence of osteoarthritis which is now the most common type of arthritis. Cartilage tissue located on articular joints erodes during osteoarthritis which causes pain and may lead to a crippling loss of function in patients. The pathophysiology of osteoarthritis has been understudied and currently no disease modifying treatments exist. The only current end-point treatment remains joint replacement surgery. The primary risk factor for osteoarthritis is age. Clinical and basic research is now focused on understanding the ageing process of cart...
Source: Sub-Cellular Biochemistry - Category: Biochemistry Authors: Tags: Subcell Biochem Source Type: research
Abstract PURPOSE:: To evaluate the short-term clinical and radiological outcomes with degenerative changes in patients over 40 years old following isolated vertical medial meniscal tear repair. METHODS:: Between 2007 and 2015, 438 patients underwent arthroscopic meniscal repair. Thirty-three patients aged over 40 years with isolated vertical medial meniscal repair (23 males and 10 females, mean age 46.1 ± 7.0; range 40-67) were included in the study. Preoperative and postoperative physical examination findings, Lysholm knee score, the International Knee Documentation Committee score, magnetic resonance...
Source: Journal of Orthopaedic Surgery - Category: Orthopaedics Authors: Tags: J Orthop Surg (Hong Kong) Source Type: research
Publication date: 23 May 2019Source: Journal of Ethnopharmacology, Volume 236Author(s): Cheryl LansAbstractEthnopharmacological relevanceThere are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset t...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
(Wiley) Osteoarthritis (OA) has traditionally been viewed as a highly prevalent but milder condition when compared with rheumatoid arthritis (RA), and some may believe that it is part of a normal aging process requiring acceptance, not treatment. A new study in Arthritis&Rheumatology indicates that OA and RA have similar impacts or burdens on patients when they first visit rheumatologists, however.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionMDHAQ/RAPID3 scores are similar in OA or RA at initial visit, but higher in OA 6 months later, reflecting superior RA treatments. The same MDHAQ/RAPID3 allows comparisons of disease burdens in different diseases.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
AbstractObjectiveThe TRIUMPH study assessed the efficacy and safety of high ‐purity synthetictrans‐capsaicin (CNTX‐4975) in subjects with chronic osteoarthritis‐associated moderate to severe knee pain.MethodsIn this double ‐blind, multicenter, phase 2 study, subjects aged 45–80 years with stable knee osteoarthritis were randomized in a 2:1:2 ratio to receive a single, intra‐articular injection of placebo, CNTX‐4975 0.5 mg, or CNTX‐4975 1.0 mg. The primary efficacy endpoint was area under the curve (AUC) for change from baseline in daily Western Ontario and McMaster Universities Osteoarthritis Index (W...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
AbstractPurposeTo describe a surgical technique in correcting valgus deformity during total knee replacement and evaluate medium-term clinical outcomes.MethodsThis was a retrospective consecutive series of total knee replacement for severe valgus deformity of patients who underwent a lateral ligament complex release with a sliver osteotomy of the lateral femoral condyle with a minimum 1-year follow-up and recording objective and patient-reported outcome measures.ResultsTwenty-three patients (25 knees) were included with median follow-up of 5  years (range 1–15 years) and average age 67.7 years (range 4...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Abstract The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases. Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small molecule inhibitors have been used for the therapeutic targeting of lncRNAs. During the last decade, phytochemicals and nutraceuticals have been explored for their potential against lncRNAs. The common lncRNAs known to be modulated by phytochemicals include ROR, PVT1, HOTAIR, MALAT1, H19, MEG3, PCAT29, PANDAR, NEAT1, and GAS5. The phytochemicals such as curcumin, resveratrol, sulforaphane, berberine, EGCG, and gambogic acid have been ...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
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