Pfizer Japan recalls high blood pressure drug Amvalo due to carcinogen

The Japanese subsidiary of Pfizer Inc is recalling a drug for high blood pressure which was found to contain a substance that can cause cancer, the drugmaker said on Friday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Conclusion Various indices of dietary quality are inversely associated with overall mortality, and selectively with cancer and cardiovascular mortality in the GCS, which contribute to the generalizability and validity of dietary guidelines.
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
Renal cell carcinoma (RCC) is one of the most frequent malignancies of the adults. Its incidence has been increasing steadily by 2–4% each year. Up to 30% of patients present with metastases at diagnosis. It is a highly vascularized cancer because of the hypoxia-induced factor stabilization as a consequence of von Hippel-Lindau inactivation. Hypoxia-induced factor accumulation leads to transactivation of molecules involved in angiogenesis including vascular endothelial growth factor (VEGF) and platelet-derived growth factor. Sunitinib is an oral tyrosine kinase inhibitor that interacts with several angiogenesis recep...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: CASE REPORTS Source Type: research
We examined the association between sleep and 891 fasting plasma metabolites in a subgroup of 106 participants from the Dietary Approaches to Stop Hypertension (DASH) —Sodium feeding trial (1997–1999). We produced two sleep variables to analyze, sleep midpoint (median time between bedtime and waketime) and sleep duration, as well as bedtime and wake time. Metabolites were measured using liquid and gas chromatography, coupled with mass spectrometry. We assesse d associations between sleep variables and log transformed metabolites using linear mixed-effects models. We combined the resulting p-values using Fisher&...
Source: Metabolomics - Category: Biology Source Type: research
Publication date: March 2019Source: European Urology Supplements, Volume 18, Issue 1Author(s): S. Tseng, S. Shiao-Jin, W. Wen-Jeng, C. Ching-Chia, J. Jhen-Hao
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Pulmonary Hypertension (PH) is classified into distinct phenotypic groups1 and patients with pulmonary arterial hypertension (PAH) belong to group 1 in the classification scheme. Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis belong to group 1 ’, PH associated with lung diseases and/or hypoxemia are classified into group 3, and chronic thromboembolic PH (CTEPH) into group 4 1. The incidence of detection of cancer after diagnosis of precapillary PH is unknown and such patients may be exposed to several carcinogens (smoking, alcohol, occu pational exposure).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Conclusion: Low parity, adjuvant pelvic radiotherapy, and peritoneal nonclosure without pelvic drainage were associated with increased lymphocele formation. In addition, a lower complication rate was found in the peritoneal partial closure with pelvic drainage group; thus, peritoneal partial closure with pelvic drainage might be suggested for women who undergo laparotomic retroperitoneal lymph node dissection.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
CONCLUSION: Apatinib monotherapy showed promising efficiency for patients with refractory colorectal cancer, especially in patients with PS 0-1 or no liver metastasis. ctDNA abundance may be a predictor in serial monitoring of tumor load. PMID: 30877190 [PubMed - as supplied by publisher]
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation, indicating atypical hemolytic uremic syndrome (HUS). The pathogenic variant inCD46 was also found in the mother who donated the kidney, indicating that the TMA occurred on the background of atypical HUS instead of severe hypertension. The patient died from disseminated cancer originated in the mother ’s kidney. Knowledge of the genetic background would have prevent...
Source: Nephron - Category: Urology & Nephrology Source Type: research
Conditions:   Cancer;   Hypertension;   Diabetes Intervention:   Device: Tailored Technology-Enhance Home-based exercise program (iHBE) Sponsors:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;   National Institute of Nursing Research (NINR) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
While the digital health market is expanding rapidly, ninety percent of start-ups will probably die within two to five years from their inception. That’s an awfully high number, so we looked around what could possibly go wrong with digital health start-ups to avoid the undeserving fate of falling into the abyss. Being an entrepreneur is tough – especially in healthcare As currently there’s an app for everything, you thought you make one that estimates the time needed to deliver food – so anyone could order pad thai from the closest place possible. Every single entrepreneur knows that a good id...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Business Health Sensors & Trackers Healthcare Design business model companies digital health digital health startups entrepreneurship future healthcare data Innovation patient design scientific scientific validation technology Source Type: blogs
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