Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere...

Source: BMC Cancer - February 7, 2019 Category: Cancer & Oncology Authors: Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini and Pier-Luigi Lollini Tags: Research article Source Type: research