Post-bacterial infection chronic fatigue syndrome is not a latent infection.

Post-bacterial infection chronic fatigue syndrome is not a latent infection. Med Mal Infect. 2019 Feb 02;: Authors: Melenotte C, Drancourt M, Gorvel JP, Mège JL, Raoult D Abstract Post-infectious chronic fatigue syndrome is a public health problem. Etiologies and physiopathological mechanisms are unknown. Some viruses are known to be involved in post-infectious chronic fatigue syndrome, but the role of bacterial infection is still questioned, especially in cases of post-treatment Lyme disease syndrome where subjective symptoms are regularly attributed to the presence of the dormant bacterium without scientific evidence. However, the medical experience of recalcitrant infections, relapses, and reactivations questions the role of "dormant bacteria" in asymptomatic latent infections as well as in subjective symptoms. We summarized scientific literature data on post-bacterial infection chronic fatigue syndrome, the role of dormant bacteria in latent infections, and bacterial asymptomatic carriage. Subjective symptoms described in post-infectious chronic fatigue syndromes are still misunderstood and there is no evidence suggesting that such symptoms could be related to dormant bacterial infection or carriage of viable bacteria. Psychological trauma may be part of these subjective symptoms. Post-infectious chronic fatigue syndrome could nonetheless be due to unknown microorganisms. Antibiotic treatment is not required for latent infections, exc...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

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Publication date: Available online 20 February 2020Source: Progress in Biophysics and Molecular BiologyAuthor(s): Gerhard GrüberAbstractMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), kills more people than any other bacterium. TB control is threatened by the continued spread of drug resistance; multi-drug and extensively drug resistant Mtb require longer, more costly, treatment with multiple drugs causing worse side effects and have a lower likelihood of treatment success. The urgent need for better treatment options for drug resistant Mtb has led the World Health Organization to prioritiz...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Molecular LiquidsAuthor(s): Bernice Rodrigues, Pravin ShendeAbstractThe aim of the research study was to explore the applications of dendrimer complexed with copper in the form of nanoclusters with drug isoniazid by acting on M. tuberculosis H37Ra (ATCC 25177) cells. This approach resulted to minimize dosage regimen, reduce toxicity and provide site-specific action through pulmonary delivery. Copper nanoclusters were prepared using template synthesis approach that includes preparation of G 4 dendrimers using Michael addition and amidation reactions and a...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
ConclusionA comparative high-resolution analysis of B*35Px or B*35Py alleles among healthy controls and HIV+ individuals showed an overrepresentation of HLA-B*35Px alleles in the healthy Indian gene pool (58%) and in the HIV+ cohort (70%). The most common B*35 subtype found among the HIV infected subjects was B*3503/55 (20%; Px group), followed by B*3501 (10%; Py group). Our study concludes that the Indian gene pool possesses higher frequency of B*35Px alleles.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Publication date: March 2020Source: The Lancet Global Health, Volume 8, Issue 3Author(s): Charbel El Bcheraoui, Honoré Mimche, Yodé Miangotar, Varsha Sarah Krish, Faye Ziegeweid, Kris J Krohn, Martin Herbas Ekat, Jobert Richie Nansseu, Zacharie Tsala Dimbuene, Helen Elizabeth Olsen, Roger C K Tine, Christopher M Odell, Christopher E Troeger, Nicholas J Kassebaum, Tamer Farag, Simon I Hay, Ali H MokdadSummaryBackgroundPeer-reviewed literature on health is almost exclusively published in English, limiting the uptake of research for decision making in francophone African countries. We used results from the Globa...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
The CDC recently updated guidelines for the treatment of latent tuberculosis infection, the first comprehensive guidelines on LTBI issued since 2000.
Source: AAFP News - Category: Primary Care Source Type: news
LYME disease is a bacterial infection which could lead to severe physical and mental problems if not diagnosed at an early stage. Spotting the early warning signs will ensure prompt treatment and noticing this peculiar feeling in the head could mean you're at risk.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 18 February 2020Source: Progress in Biophysics and Molecular BiologyAuthor(s): Bei Shi Lee, Ekaterina Sviriaeva, Kevin PetheAbstractMycobacterium tuberculosis strictly depends on oxygen to multiply, and the terminal oxidases are a vital part of the oxidative phosphorylation pathway. The bacterium possesses two aerobic respiratory branches: a cytochrome bcc-aa3 and a bacteria-specific cytochrome bd oxidase. The identification of small-molecule inhibitors of the cytochrome bcc-aa3 under numerous experimental conditions reflects the essentiality of the pathway for the optimum growth of M. tu...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Conclusions Histology is proved to be an accurate diagnostic tool in TS. Suppurative forms of TS without granuloma are rare and represent the main cause of false-negative histology. Suggestive histology of TS does not rule out fungal and brucellar spondylodiscitis. Caseous necrosis is not pathognomonic of tuberculosis. Fungal infection can also exhibit such type of necrosis.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
This study aimed to investigate a series of patients diagnosed with LTBI during screening before immunosuppressive therapy, describing how the use of diagnostic tests and treatment evolved over time. This retrospective cohort study included all individuals diagnosed with LTBI during screening before intended immunosuppressive therapy in a tertiary care hospital between January 2000 and December 2017. Evidence for LTBI, including history, tuberculin skin test (TST), QuantiFERON (QFT) result and suggestive lesions on chest radiography (CXR), and CT scan if available, was analyzed. The study included 295 individuals with LTBI...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractTuberculosis in London occurs at a rate of 19 cases per 100,000 population, with a significant proportion diagnosed as extra-pulmonary infection. At Barts Health NHS Trust, our TB rates are much higher than the London average and approximately 60% cases are extra-pulmonary in nature. We evaluated the BD MAX ™ MDR-TB assay as a molecular tool for rapid diagnosis of TB. One hundred twenty-eight specimens, encompassing pulmonary (70) and extra-pulmonary (58) infection, were tested using the BD MAX™ MDR-TB assay and compared with smear and liquid culture results, to determine PCR performance. The BD MA X&tr...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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