Overexpression of TONSL might be an independent unfavorable prognostic indicator in hepatocellular carcinoma.

CONCLUSIONS: TONSL holds promise for serving as a prognostic biomarker for HCC. DNA amplification, hypomethylation and miR-133b downregulation could be the mechanisms associated with TONSL upregulation in HCC. TONSL might function as an oncogene via cell cycle regulation pathways in HCC. PMID: 30723051 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30723051?dopt=Abstract

Source: Pathology, Research and Practice - January 30, 2019 Category: Pathology Authors: Yu B, Ding Y, Liao X, Wang C, Wang B, Chen X Tags: Pathol Res Pract Source Type: research