Histamine-driven responses are sustained via a bioactive metabolite

A histamine metabolite, imidazole acetic acid (IAA), recapitulates key histamine-driven biology, including recruitment of eosinophils, induction of itch, and induction of anaphylaxis. IAA may perpetuate anaphylactic and other allergic responses after the initial release and metabolism of histamine.

Source: Journal of Allergy and Clinical Immunology - February 7, 2019 Category: Allergy & Immunology Authors: Tania E. Velez, Adam J. Byrne, Joshua B. Wechsler, Rebecca A. Krier-Burris, Kathryn E. Hulse, Paul J. Bryce Source Type: research