The Patient Had Bone Cancer. The Diagnosis Arrived 240 Million Years Too Late.

The fossil of an ancient animal teaches a sad lesson: Cancer has been around for a very, very long time.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Bone Cancer Tumors Turtles and Tortoises Fossils Paleontology Reptiles Charite Universitatsmedizin (Berlin, Germany) JAMA Oncology (Journal) Museum of Natural History (Berlin, Germany) Berlin (Germany) your-feed-science Source Type: news

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In this study, an expression of ERp29 was examined in patient-derived osteosarcoma cells (7 cases) and normal bone graft-derived osteoblasts (7 cases) using western blotting. Expression profile of ERp29 in 94 osteosarcoma cases was investigated using immunohistochemically stained on formalin-fixed paraffin-embedded biopsied tissue. An association with clinicopathologic parameters and the patient survival was evaluated.Results: The results substantiate the outcome from the proteomic study in which ERp29 expression was significantly higher in primary osteosarcoma cells compared to osteoblastic cells. Immunohistochemical anal...
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology GroupCorrection: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group, Published online: 18 March 2019; doi:10.1038/s41416-019-0424-7Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
In conclusion, these results suggested that EPEL may promote the migration and invasion of osteosarcoma cells by upregulating ROCK1. PMID: 30867743 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 14 March 2019Source: Journal of Molecular StructureAuthor(s): Guang Lv, Chong-Lan YinAbstractA new heterocyclic compound 7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(3H)-one (1), designed using methyl 5-hydroxy-4-methoxy-2-nitrobenzoate (2) as the starting material, was successfully obtained via multiple synthesis route and finally characterized by fourier transform infrared (FT-IR) spectroscopy, 1H nuclear magnetic resonance (NMR), and single crystal X-ray crystallography. We investigated its effect on cell viability and proliferation with Cell Counting Kit-8 (CCK8) assay. The results r...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 14 March 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Xiao Chu, Liang Mao, Omar Johnson, Kang Li, Jonathan Phan, Qingshui Yin, Lihua Li, Junying Zhang, Wei Chen, Yu ZhangAbstractRadical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO2 nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy) as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO2 nanoparticles coul...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is overexpressed in many cancers. To identify its roles in tumors, we employed 143B osteosarcoma cells and HCC1806 triple-negative breast cancer cells with or without ASCT2 deletion. ASCT2ko 143B cells grew well in standard culture media, but ASCT2 was required for optimal growth at
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Membrane Biology Source Type: research
Abstract In current study, a bioinformatic-based network pharmacology was used to identify the osteosarcoma (OGS)-pathological targets and formononetin (FN)-treated targets before the main core predictive biotargets were screened. In addition, all core targets were selected through a number of bioinformatic databases, followed by identification of predominant biological processes and signalling pathways of FN anti-OGS. Further, top three core targets of FN anti-OGS were determined as oestrogen receptor 1 (ESR1), tumour protein p53 (TP53), receptor tyrosine-protein kinase erbB-2 (ERBB2) respectively. In clinical bi...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
In conclusion, the present study revealed PI‑1840 to be a promising drug for the treatment of OS. PMID: 30864717 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MicroRNA‑708 inhibits the proliferation and invasion of osteosarcoma cells by directly targeting ZEB1. Mol Med Rep. 2019 Mar 06;: Authors: He J, Xiang D, Lin Y Abstract Numerous microRNAs (miRNAs) have been identified as aberrantly expressed in osteosarcoma (OS). miRNAs serve important roles in the pathogenesis of OS as oncogenes or tumor suppressors. Recent studies revealed that miR‑708‑5p (miR‑708) was dysregulated in various types of human cancer; however, its roles and underlying molecular mechanisms in OS remain unknown. Therefore, the present study aimed to determine miR‑708 expression ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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