Parkinson’s disease symptoms: What to look for in your face - sign linked to condition

PARKINSON ’S disease symptoms usually develop gradually and appear mild in the early stages. They mostly affect a person’s physical movement, and that being said, there’s one sign in the face to look out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 23 May 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Inmaculada Banegas, Ana B. Segarra, Isabel Prieto, Francisco Vives, Marc de Gasparo, Raquel Duran, Juan de Dios Luna, Manuel Ramírez-SánchezAbstractAminopeptidase A is responsible for the hydrolysis of angiotensin II and cholecystokinin. By measuring its activity we obtain a reflection of the functional status of its endogenous substrates. Dopamine coexists with these neuropeptides in striatum and prefrontal cortex. If the content of any of them is altered, the others and the functions they are involved in w...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 24 May 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Alejandra Lucía Marcos, Gerardo Raul Corradi, Luciana Romina Mazzitelli, Cecilia Irene Casali, María del Carmen Fernández Tome, Hugo Pedro Adamo, Felicitas de Tezanos PintoAbstractMutations in the ATP13A2 gene (PARK9, CLN12, OMIM 610513) were initially associated with a form of Parkinson's Disease (PD) known as Kufor Rakeb Syndrome (KRS). However, the genetic spectrum of ATP13A2-associated disorders was expanded in the last years, because it has been found to underlay variants of neuronal ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Authors: Seritan AL, Rienas C, Duong T, Delucchi K, Ostrem JL Abstract OBJECTIVE: Parkinson's disease (PD) is a quintessential neuropsychiatric condition in which anxiety and depressive symptoms are common and may precede motor manifestations. The authors explored the ages at onset of anxiety and depressive disorders among patients with PD evaluated by psychiatrists at a deep brain stimulation center. METHODS: Psychiatric diagnoses and ages at onset were collected via clinical interviews. The ages at PD diagnosis were ascertained by chart review. Onset ages for anxiety and depressive disorders (overall and for ...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
ConclusionWe used gold nanoparticles loaded exosomes for in-vivo neuroimaging and present specific migration and homing to various brain pathologies including stroke, Parkinson's, Alzheimer's, Autism and healthy brains as a control. By this method, we visualized the migration and homing abilities of exosomes in long-term follow-up ad report that in pathological areas they home for more than 96 hours while in healthy brains they are being evacuated within 24 hours. Furthermore, we show that MSC-exo uses chemotaxis signaling to target the inflammatory areas in the brain.
Source: Cytotherapy - Category: Cytology Source Type: research
This article covers the pharmacological treatment of depression in PD; this involves standard antidepressant treatment such as selective serotonin reuptake inhibitors, tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors, and monoamine oxidase inhibitors. As with depression not associated with PD, most treatment is partially successful. Non-pharmacological approaches are also touched upon. Expert opinion: Most antidepressant therapy shows partial efficacy in patients with PD. However, there is a need for better study design as well as more comparative studies for the treatment of depression in PD. Bi...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Ghada Omar Tuffaha, Mamon M. Hatmal, Mutasem O. TahaAbstractThe kinase c-Jun N-terminal Kinase 3 (JNK3) plays an important role in neurodegenerative diseases. JNK3 inhibitors have shown promising results in treating Alzheimer's and Parkinson's diseases. This prompted us to model this interesting target via three established structure-based computational workflows; namely, docking-based Comparative Intermolecular Contacts Analysis (db-CICA), pharmacophore modeling via molecular-dynamics based Ligand-Receptor Contact A...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Condition:   Parkinson Disease Intervention:   Other: Speech therapy Sponsors:   Radboud University;   Michael J. Fox Foundation for Parkinson's Research Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributors : Akinori Miyashita ; Hiroyuki Hatsuta ; Masataka Kikuchi ; Akihiro Nakaya ; Yuko Saito ; Tamao Tsukie ; Norikazu Hara ; Soichi Ogishima ; Nobutaka Kitamura ; Kohei Akazawa ; Akiyoshi Kakita ; Hitoshi Takahashi ; Shigeo Murayama ; Yasuo Ihara ; Takeshi Ikeuchi ; Ryozo KuwanoSeries Type : Expression profiling by arrayOrganism :Transcriptome analysis of post-mortem brain tissue specimens from three brain regions (BRs), entorinal, temporal and frontal cortices, of 71 Japanese brain-donor subjects to identify genes relevant to the expansion of neurofibrillary tangles. In total, 213 brain tissue specimens (= 71 sub...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
Apathy is a prominent non-motor symptom in Parkinson ’s disease (PD). People with apathy show a lack of emotion, passion, and motivation. Between 17 and 70% of persons with PD have apathy; the extreme heterogen...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
This study compared zonisamide and other anti-PD drugs by analyzing their associations with the incidence of PD-relevant symptoms.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
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