Dementia in Down syndrome: unique insights for Alzheimer disease research

Dementia in Down syndrome: unique insights for Alzheimer disease researchDementia in Down syndrome: unique insights for Alzheimer disease research, Published online: 07 February 2019; doi:10.1038/s41582-018-0132-6Alzheimer disease (AD) pathology is found in almost all adults with Down syndrome (DS), primarily owing to overexpression of APP, present on chromosome 21. Here, Lott and Head examine the commonalities and disparities between DS and AD and highlight findings in DS that can inform research into AD in the general population.

Source: Nature Reviews Neurology - February 7, 2019 Category: Neurology Authors: Ira T. Lott Elizabeth Head Source Type: research