For EGFR- and ALK-Driven Lung Cancers, Use'Best Drug First'For EGFR- and ALK-Driven Lung Cancers, Use'Best Drug First '

Dr Mark Kris discusses current therapeutic strategies for patients with EGFR- and ALK-driven lung cancers.Medscape Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

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Publication date: Available online 23 May 2019Source: Journal of Cancer PolicyAuthor(s): Steve Langton, Derek Lowe, Simon N Rogers, Annette Plüddemann, Clare BankheadAbstractBackgroundThe ‘two-week rule’ (TWR) fast-track cancer referral system for head and neck cancers was introduced by the UK government in 2000, to facilitate earlier diagnosis. However, little work has compared stage on diagnosis of cancer before and after the implementation of the system.Objectives•Describe the presentation of oral cancer in Merseyside from 1992-2012.•To evaluate whether stage on presentation has improved after...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
ConclusionsThe investigative team developed a novel breast cancer treatment DA that is acceptable to women ≥70 years with a history of ER+, HER2-, early stage breast cancer. Next, the DA's efficacy needs to be tested with diverse older women newly diagnosed with breast cancer.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Upma Sharma, Pallavi Singhal, Kapil Bandil, Rajeshwar Patle, Anoop kumar, Kausar Neyaz, Surojit Bose, Ajay Kumar Dewan, Ravi Mehrotra, Veena Sharma, Mausumi BharadwajAbstractBackground: Despite being most preventable malignancies associated with smoked and smokeless tobacco products, squamous cell carcinoma of oral cavity is one of the most common malignancy in India. The aim of the present study was to evaluate the role of TLRs in oral pre-cancerous, cancerous cases and their genotypic correlation with HPV/EBV, co-infection &lifestyle habits...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: Cancer CellAuthor(s): Ruidong Xue, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, Xiwen Liao, Qiang Gao, Shota Sasagawa, Yanmeng Li, Jincheng Wang, Hua Guo, Qi-Tao Huang, Qian Zhong, Jing Tan, Lisha Qi, Wenchen Gong, Zhixian Hong, Meng LiSummaryWe performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Black men with nonmetastatic prostate cancer did not appear more likely to die from this disease than white men when given similar access to care and standardized treatment, an analysis found.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Publication date: Available online 24 May 2019Source: Materials Chemistry and PhysicsAuthor(s): Gururaj M. Neelgund, Makobi C. Okolie, Folami K. Williams, Aderemi OkiAbstractA novel NIR (near infrared) active photothermal agent, CNTs-PAMAM-Ag2S has been synthesized by covalent grafting of polyamidoamine (PAMAM) to carbon nanotubes (CNTs) and subsequent deposition of Ag2S nanocrystallites. The potential of CNTs-PAMAM-Ag2S as a NIR active photothermal agent was preliminarily accessed by its electronic absorption spectrum measured in UV–vis–NIR region. The CNTs-PAMAM-Ag2S exhibited excellent photothermal effect an...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: Available online 23 May 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Giovanni Blandino, Fabio Valenti, Andrea Sacconi, Silvia Di AgostinoAbstractDeregulated cell metabolism is one of the cancer hallmarks. Mitochondrial DNA mutations and enzyme defects, aberrant tumor suppressor or oncogenic activities cause mitochondrial dysfunction leading to deregulated cellular energetics. The tumor suppressor protein, p53 is a tetrameric transcription factor that in response to diverse genotoxic and non-genotoxic insults activates a plethora of target genes to preserve genome integrity. In the las...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
Publication date: Available online 23 May 2019Source: CellAuthor(s): Ninib Baryawno, Dariusz Przybylski, Monika S. Kowalczyk, Youmna Kfoury, Nicolas Severe, Karin Gustafsson, Konstantinos D. Kokkaliaris, Francois Mercier, Marcin Tabaka, Matan Hofree, Danielle Dionne, Ani Papazian, Dongjun Lee, Orr Ashenberg, Ayshwarya Subramanian, Eeshit Dhaval Vaishnav, Orit Rozenblatt-Rosen, Aviv Regev, David T. ScaddenSummaryStroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma have defined individual populations in th...
Source: Cell - Category: Cytology Source Type: research
ConclusionTo that end, a KID syndrome cell line (KID-KC) was established from primary keratinocytes of a KID syndrome patient with heterozygous p.D50N mutation, which displayed impaired gap junction intercellular communication and hyperactive hemichannels, confirmed by dye transfer, patch clamp and neurobiotin uptake assays. In KID-KCs, treatment with AS-siRNA led to robust inhibition of the mutant GJB2 allele without altering expression of the wildtype allele. This resulted in correction of both gap junction intercellular communication and hemichannel activity. Furthermore, AS-siRNA treatment caused only low-level off-tar...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe have designed several spiral microfluidic devices of various dimensions with enrichment and depletion outlets. We investigated the feasibility of using these devices to purify lymphocytes and more specifically T-cells from the leukocytes isolated from peripheral blood. We investigated the effect of channel dimensions, flow rate and microfluidic pressure on the separation of isolated leukocytes and determined the effect on cell viability and proliferation. The device was first optimized using a mixture of two cell lines differing in size; small Raji B lymphoblast-like cells and large A549 cells. We achieved 89 ...
Source: Cytotherapy - Category: Cytology Source Type: research
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