Reinterpretation of BRCA1 and BRCA2 variants of uncertain significance in patients with hereditary breast/ovarian cancer using the ACMG/AMP 2015 guidelines.

CONCLUSIONS: Since the clinical significance of VUS in BRCA1/2 may vary from time to time, reinterpretation of the VUS results could contribute to clinical decision-making. PMID: 30725392 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30725392?dopt=Abstract

Source: Breast Cancer - February 6, 2019 Category: Cancer & Oncology Authors: So MK, Jeong TD, Lim W, Moon BI, Paik NS, Kim SC, Huh J Tags: Breast Cancer Source Type: research