Radiosensitizing properties of magnetic hyperthermia mediated by superparamagnetic iron oxide nanoparticles (SPIONs) on human cutaneous melanoma cell lines

Publication date: March–April 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 2Author(s): Jakub Dalibor RybkaAbstractMelanoma is responsible for the majority of deaths related to skin cancer. Worryingly, prognoses show an increasing number of melanoma cases each year worldwide. Radiotherapy, which is a cornerstone of cancer treatment, has proved to be useful but insufficient in melanoma management due to exceptionally high radioresistance of melanoma cells. This problem could be overcome by superparamagnetic iron oxide nanoparticles (SPIONs) used as heat mediators in magnetic hyperthermia, which not only enhance radiosensitivity, but also enable precise targeting by exploitation of their magnetic properties.Graphical abstract
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research