Could hamsters provide new clues to Alzheimer's?

A study by CEU San Pablo University in Madrid found that when Syrian hamsters hibernate, their brains undergo structural changes that help their neurons survive even during low temperatures.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In this study, we developed a highly sensitive method for simultaneous detection of 34 SCFAs by stable isotope labeling coupled with ultra-high performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS/MS) analysis. In this respect, a pair of isotope labeling reagents, N-(4-(aminomethyl)benzyl)aniline (4-AMBA) and N-(4-(aminomethyl)benzyl)aniline-d5 (4-AMBA-d5), were synthesized to label SCFAs from the feces of mice and SCFA standards, respectively. The 4-AMBA-d5 labeled SCFAs were used as internal standards to compensate the ionization variances resulting from matrix effect and thus minimiz...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a generative model. A reference morphology is deformed along specific trajectories to match subject specific morphologies. It is used to define two imaging progression markers: 1) a morphological age and 2) a disease score. These markers can be computed regionally in any brain region.The approach is evaluated on brain structural magnetic resonance images (MRI) from the ADNI database. The mo...
Source: NeuroImage - Category: Neuroscience Source Type: research
In this section of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD will discuss the following 6 articles: 1. Brownlee WJ, Miszkiel KA, Tur C, Barkhof F, Miller DH, Ciccarelli O. Inclusion of optic nerve involvement in dissemination in space criteria for multiple sclerosis. Neurology. 2018;91:e1130–e1134. 2. Cossack M, Nabrinsky E, Turner H, Abraham A, Gratton S. Timolol eyedrops in the treatment of acute migraine attacks: a randomized crossover study. JAMA Neurol. 2018;75:1024–1025. 3. Rotenstein LS, Torre M, Ramos MA, Rosales RC, Guille C, Sen S, Mata DA. Prevalence of burnout amo...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Literature Commentary: June Issue Double Feature Source Type: research
Objective: The present study investigates viscoelastic properties of human autopsy brain tissue via nanoindentation to find feasible biomarkers for Alzheimer's disease (AD) in $ex$ $vivo$ condition and to understand the mechanics of the human brain better, especially on the difference before and after progression of AD. Methods: Viscoelastic properties of paraformaldehyde-fixed, paraffin-embedded thin (8 $mu text{m}$) sectioned normal and AD affected human autopsy brain tissue samples are investigated via nanoindentation with a combined loading profile of a linear preloading and a sinusoidal loading at various loadi...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 19 May 2019Source: Neuroscience LettersAuthor(s): Laia Pérez-Roca, Patricia Prada-Dacasa, Cristina Segú-Vergés, Ana Gámez-Valero, María A. Serrano-Muñoz, Cristina Santos, Katrin BeyerMutations in the glucocerebrosidase (GCase) gene (GBA) and GCase deficiency are major risk factors for Lewy body diseases. Decreased GCase activity enhances alpha-synuclein aggregation and disease development. Lysosomal integral membrane protein type 2, encoded by SCARB2, binds GCase targeting it to lysosomes and transcription factor EB (Tfeb) regulates lysosomal prot...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
(Medical College of Georgia at Augusta University) Scientists want to know whether our aging fat cells are important to the onset and progression of Alzheimer's. They have evidence that as we age, our fat becomes less efficient at producing a hormone that helps support the growth and survival of neurons and helps regulate their activity. The result can be neurons in areas of the brain important to learning and memory become dysfunctional, degenerate and we develop Alzheimer's.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Van Andel Research Institute) Scientists have identified a new mechanism that accelerates aging in the brain and gives rise to the most devastating biological features of Alzheimer's disease. The findings also unify three long-standing theories behind the disease's origins into one cohesive narrative that explains how healthy cells become sick and gives scientists new avenues for screening compounds designed to slow or stop disease progression, something existing medications cannot do.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
...Developing dementia doesn’t take away your individuality or humanity any more than developing cancer or diabetes. Therefore, rather than concentrate only on drugs, we need to help caregivers – and yes professionals – better understand how to help people living with dementia cope with the negative aspects of their illness so that they can live the best life that they can. Read more about the spectrum of Alzheimer's disease (and hope) on HealthCentral: Carol Bradley Bursack is the Candid Caregiver MedicareFAQ – Medicare Resource Center Support a caregiver or jump-start discussion in support groups ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
In this study, we have examined the molecular mechanism of the toxicity of acetylated K274-tau. We incorporated an acetylation mimicking mutation at K274 (K->Q) residue of tau. The mutation (K274Q) strongly reduced the ability of tau to bind to tubulin and also to polymerize tubulin while K274R mutation did not reduce the ability of tau either to bind or polymerize tubulin. In addition, K274Q-tau displayed a higher aggregation propensity than wild-type tau as evident from thioflavin S fluorescence, tryptophan fluorescence, and electron microscopic images. Furthermore, dynamic light scattering, atomic force microscopy, a...
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Research Articles Source Type: research
AbstractDiabetes mellitus is metabolic syndrome and a risk factor for cognitive dysfunction-related diseases such as dementia, especially Alzheimer ’s disease (AD), which is associated with chronic inflammation and abnormal insulin signaling pathway. Exercise, a known potential therapy for diabetes, can also alleviate neurodegeneration. We evaluated the effects of aerobic exercise on inflammation and insulin signaling pathway in the prefronta l cortex of diabetic rats. Male SD rats were fed with a normal diet or a high-fat diet (HFD) for 8 weeks. Then, part of the HFD rats was selected for aerobic exercise train...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
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