Basic fibroblast growth factor induces adipogenesis in orbital fibroblasts; implication for the pathogenesis of graves' orbitopathy.

CONCLUSION: bFGF induces adipogenesis in orbital fibroblasts and as such may contribute to GO. The additive effect of bFGF and PDGF-BB on adipogenesis along with the observed inhibitory effects of dasatinib and nintedanib point at independent receptor mediated effects. This supports the hypothesis that multitarget directed therapy might be more efficient in the treatment of GO.
PMID: 30724135 [PubMed - as supplied by publisher]

Source: Thyroid : official journal of the American Thyroid Association - February 7, 2019 Category: Endocrinology Tags: Thyroid Source Type: research