Dysregulations of sonic hedgehog signaling in MED12 ‐related X‐linked intellectual disability disorders

ConclusionsThese results support a critical role of MED12 in regulating Gli3 ‐dependent SHH signaling and in developing ID and related congenital malformations in XLID syndromes. Differences in the expression profile of SHH‐signaling genes potentially contribute to variability in clinical phenotypes in patients withMED12‐related XLID disorders.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Publication date: Available online 13 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Sofia Zahia, Maria Begoña Garcia Zapirain, Xavier Sevillano, Alejandro González, Paul J. Kim, Adel ElmaghrabyAbstractPressure injuries represent a tremendous healthcare challenge in many nations. Elderly and disabled people are the most affected by this fast growing disease. Hence, an accurate diagnosis of pressure injuries is paramount for efficient treatment. The characteristics of these wounds are crucial indicators for the progress of the healing. While invasive methods to retrieve information are not ...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
This study aimed to assess the associations among neighborhood walkability and functional disability in older adults. Methods The study included a community-based, random sample of 410 community-dwelling adults aged ≥60 years old in Viços...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: November 2019Source: Spine Deformity, Volume 7, Issue 6Author(s): Jussi P. Repo, Ville T. Ponkilainen, Arja H. Häkkinen, Jari Ylinen, Paula Bergman, Kati KyröläAbstractStudy DesignObservational cohort study.ObjectivesTo measure and compare the structural validity of the Oswestry Disability Index (ODI) and the Scoliosis Research Society–30 (SRS-30) questionnaire in an adult population with prolonged degenerative thoracolumbar disease.Summary of Background DataThe ODI and the SRS-30 are commonly used patient-reported outcome instruments to assess back-specific disability and symptoms re...
Source: Spine Deformity - Category: Orthopaedics Source Type: research
ConclusionsTHR improved HRQOL. BMI was the only significant independent factor that was negatively correlated with HRQOL.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
This study aims to examine the effectiveness of the postural treatment of the Mézières method on elite rhythmic gymnastics athletes with low back pain. DESIGN: Double-blind, randomized, controlled trial. SETTING: The sports hall of "Puente Tocinos," Murcia, Spain. PARTICIPANTS: Ninety gymnastics athletes were randomized into 2 parallel groups (intervention: n = 39; control: n = 51), of whom 98.9% were women (women = 89; man = 1). INTERVENTION: The Mézières method postural therapy was implemented. It lasted about 60 minutes in repeated sessions of 2 to 3 meetings per wee...
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
This study investigated the therapeutic effects of human breast milk stem cell (BMSC)-conditioned medium (BMSC-CM) in a model of spinal cord injury (SCI) in male Sprague-Dawley rats. Overview of Literature: SCI is one of the leading causes of disability in addition to sensory and motor impairment. So far, there have been no successful treatments for SCI. Given the positive outcomes associated with using stem cells and their derivatives as a treatment for various diseases, there is a growing interest in using them as an SCI treatment. Recent research has demonstrated that CM from stem cells has therapeutic advantages. ...
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Notice from the Centers for Medicare and Medicaid Services (CMS) announcing Medicare's Hospital Insurance (Part A) premium for uninsured enrollees in calendar year (CY) 2020. The premium is paid by enrollees age 65 and over who are not otherwise eligible for Part A benefits and by certain disabled individuals who have exhausted other entitlement. This premium is effective on January 1, 2020.
Source: Federal Register updates via the Rural Assistance Center - Category: Rural Health Source Type: news
Conclusion These are some of the things I would love to tell my younger self. What are some tips you would tell a younger you if you had the chance? Please share them with us in the comments. It will be interesting to see different perspectives and learn from them. You've read Overcoming Challenges: A Message to my Younger Self, originally posted on Pick the Brain | Motivation and Self Improvement. If you've enjoyed this, please visit our site for more inspirational articles.
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured self improvement life lessons motivation Source Type: blogs
[IPS] Nairobi, Kenya -For each of the 830 women dying each day from pregnancy complications and childbirth, an estimated 20 others suffer serious injuries, infections or disabilities.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Authors: Malone Q, Passmore S, Maiers M Abstract Different techniques used to analyze and reduce accelerometer data may impact its interpretation. To determine which variables were impacted by changing analysis parameters, the authors performed a secondary analysis of data gained from a clinical trial conducted on older adults (aged ≥65 years; M = 71.1 and SD = 5.3; n = 100) with neck and back disabilities and compared the effects of two different cut- point sets (Matthews and Freedson sets) commonly used to analyze older adult accelerometry data. The Matthews set was found to assign significantly greater m...
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research
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