Effects of antipsychotics with different weight gain liabilities on human in vitro models of adipose tissue differentiation and metabolism

Publication date: 1 December 2011 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 35, Issue 8 Author(s): Andréa L. Sertié , Angela May Suzuki , Rogério A.L. Sertié , Sandra Andreotti , Fábio B. Lima , Maria Rita Passos-Bueno , Wagner F. Gattaz Weight gain and metabolic abnormalities are serious side effects associated with the use of several second generation antipsychotics (SGA). The adipose tissue has been considered a direct SGA target involved in the development of these adverse effects. Recent studies, mainly using murine cells, have suggested that SGA increase both adipogenesis of preadipocytes and lipid accumulation in mature adipocytes. However, to date there has been little research comparing the effects of antipsychotics with different propensities to induce weight gain on human in vitro models of white adipose tissue neoformation and metabolism. The present study aimed to investigate the effects of antipsychotics either strongly associated with weight gain, such as the SGA clozapine and olanzapine, or not, such as the SGA ziprasidone and the classical antipsychotic haloperidol, on proliferation and adipocyte differentiation of human adipose-derived stem cells (ADSCs) and lipogenesis in human mature adipocytes. Whereas ziprasidone induced elevated levels of cell death during adipogenesis and could not be investigated further, we observed that clozapine, olanzapine and haloperidol had slight stimulatory effects on the tra...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research