Endocannabinoid system, a target to improve cognitive disorders in models of Down syndrome

(Universitat Pompeu Fabra - Barcelona) A study by the Neuropharmacology Laboratory-NeuroPhar of the Department of Experimental and Health Sciences (DCEXS) at UPF reveals the involvement of the endocannabinoid system in cognitive disorders in mouse models of Down syndrome. The work, led by Andr é s Ozaita and Rafael Maldonado, which has been published in the journal Neurobiology of Disease, also identifies cannabinoid receptor type-1 (CB1) as a potential treatment target.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Kubota M Abstract Recent evidence suggests that hyperuricemia is an important condition in children and adolescents, particularly in association with noncommunicable diseases. This review aims to summarize our current understanding of this condition in pediatric patients. An analysis of serum uric acid reference values in a healthy population indicates that they increase gradually with age until adolescence, with differences between the sexes arising at about 12 years of age. This information should be taken into consideration when defining hyperuricemia in studies. Gout is extremely rare in childre...
Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
Background: Various ocular anomalies are present in the vast majority of individuals with Down syndrome; however, we know little about optic nerve abnormalities. The aim of this cross-sectional comparative study was to describe optic disc morphology in patients with Down syndrome and to determine if the differences found are potentially related to visual acuity. Subjects/methods: Assessable fundus images were obtained in 50 children with Down syndrome and 52 children without Down syndrome. Morphological analysis of the optic nerve was performed, including the disc-to-macula distance (DM) to disc diameter (DD) ratio (DM...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
American Journal on Intellectual and Developmental Disabilities,Volume 124, Issue 4, Page 293-308, July 2019.
Source: American Journal on Intellectual and Developmental Disabilities - Category: Disability Authors: Source Type: research
Among children with Down syndrome, the frequency of motor rehabilitation intervention and the age at the start of this intervention are independently related to the age at onset of independent walking. Early motor rehabilitation, before age 6  months, may be effective in reducing motor delay in children with Down syndrome.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Brief Reports Source Type: research
American Journal on Intellectual and Developmental Disabilities,Volume 124, Issue 4, Page 324-338, July 2019.
Source: American Journal on Intellectual and Developmental Disabilities - Category: Disability Authors: Source Type: research
American Journal on Intellectual and Developmental Disabilities,Volume 124, Issue 4, Page 354-373, July 2019.
Source: American Journal on Intellectual and Developmental Disabilities - Category: Disability Authors: Source Type: research
Condition:   Physical Therapy Intervention:   Device: core stability exercises and treadmill training exercises Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 12 June 2019Source: Fish &Shellfish ImmunologyAuthor(s): Tze Hann Ng, Ramya Kumar, Kantamas Apitanyasai, Shu-Ting He, Shen-Po Chiu, Han-Ching WangAbstractArthropod hypervariable Dscam (Down syndrome cell adhesion molecule) may be involved in adaptive-like immune characteristics, namely immune priming, enabling the host to “learn” and “remember” pathogens previously encountered in arthropods. However, expression of Dscam in immune-primed arthropods after a second challenge has apparently not been confirmed. Herein, working with Dscam of Australian freshwater cra...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Condition:   Physical Therapy Intervention:   Device: core stability exercises and treadmill training exercises Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractCurcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti ‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This...
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research
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