Curative Treatment of Prosthetic Joint Infection in Patients Younger than 80 vs. 80 or Older

Publication date: Available online 6 February 2019Source: Joint Bone SpineAuthor(s): Chloé Jamakorzyan, Vanina Meyssonnier, Younes Kerroumi, Benoit Villain, Beate Heym, Luc Lhotellier, Valérie Zeller, Jean-Marc Ziza, Simon MarmorResumeObjective: Prosthetic joint infection (PJI) is a serious complication of joint replacement surgery. The major pharmacological and surgical treatments required by PJI increase the risk of peri-operative complications in elderly patients. The increase in life expectancy combined with procedural advances make these treatments possible even in the oldest patients. Here, our objective was to compare the characteristics and outcomes of curative PJI treatment in patients
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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Authors: Dowdy RAE, Emam HA, Cornelius BW Abstract Ludwig's angina (LA) is a gangrenous cellulitis of the neck that spreads via continuity of the fascial planes. Treatment of LA includes aggressive antibiotic therapy as well as surgical drainage in many cases. The most common cause of infection is odontogenic and can be due to both aerobic and anaerobic bacteria. Signs and symptoms of LA include bilateral cervical swelling, dysphagia, drooling, neck tenderness, elevation and posterior distension of the tongue, restricted neck movement, trismus, dyspnea, and stridor, which can result in difficult airway management. ...
Source: Anesthesia Progress - Category: Anesthesiology Tags: Anesth Prog Source Type: research
CONCLUSION: Hair tourniquet syndrome should be kept in mind as an etiology in infants with toe and finger strangulation. These patients should be examined undressed. Immediate removal of hair is an effective treatment method to save appendage. LEVEL OF EVIDENCE: Level IV, Therapeutic Study. PMID: 31104884 [PubMed - as supplied by publisher]
Source: Acta Orthopaedica et Traumatologica Turcica - Category: Orthopaedics Authors: Tags: Acta Orthop Traumatol Turc Source Type: research
Kay B. Barnes1†, Karleigh A. Hamblin1†, Mark I. Richards1, Thomas R. Laws1, Andreas Vente2, Helen S. Atkins1,3,4 and Sarah V. Harding1* 1Defence Science and Technology Laboratory, Salisbury, United Kingdom 2MerLion Pharmaceuticals, Berlin, Germany 3University of Exeter, Exeter, United Kingdom 4London School of Hygiene &Tropical Medicine, London, United Kingdom The efficacy of the novel fluoroquinolone finafloxacin was evaluated as a potential therapeutic in vitro and in vivo, following an intranasal infection of Francisella tularensis strain SchuS4 in BALB/c mice. We demonstrated that short t...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: New carbapenem/βLI combinations may be viable alternatives to antimicrobial combination therapy as they displayed high efficacy in vitro and in vivo. Meropenem/Avibactam and Meropenem/Relebactam should be tested on larger sample sizes with different carbapenemases before progressing further in its preclinical development. Introduction Carbapenem resistant Gram-negative bacteria have been gradually increasing in prevalence in recent years. In the United States, the latest CDC Antibiotic Resistance Threat Report indicates that Carbapenem-Resistant Enterobacteriaceae (CREs) are responsible for 9,000 a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, the full-length PcrV was divided into four domains with the guidance of its structure, and the Nter domain (Met1-Lys127) and H12 domain (Leu251-Ile294) were found to be immunodominant. Subsequently, Nter and H12 were combined with a flexible linker to generate an artificial PcrV derivative (PcrVNH). PcrVNH was successfully produced in E. coli and behaved as a homogenous monomer. Moreover, immunization with PcrVNH elicited a multifactorial immune response and conferred broad protection in an acute PA pneumonia model and was equally effective to full-length PcrV. In addition, passive immunization with anti-Pcr...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Throughout my career as a simulation educator, I noticed that students would often return to the simulation center to go through a case that was very similar to previous cases they’d managed, whether or not they’d successfully managed the previous cases. Yet, despite our best efforts at providing feedback through quality debriefing, they could not apply the previously acquired knowledge and skills into this new, similar situation (i.e., transfer of learning would not occur). This is a constant finding in the cognitive psychology and transfer literature.1–3 We looked at this literature to come up with t...
Source: Academic Medicine Blog - Category: Universities & Medical Training Authors: Tags: Featured Guest Perspective debriefing learners teaching Source Type: blogs
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Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This article provides a summary of the most recent clinical evidence and professional guidelines for the diagnosis and treatment of the sepsis in the critical care setting.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional Pulmonology Source Type: research
Conclusions: Isolated corneal Acremonium eumycetoma masquerading as a perforated corneal ulcer with prolapsed uveal tissue is a rare entity. Surgical intervention and appropriate antimicrobial therapy are key to successful outcome.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
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