Clinical and MRI correlates of CSF neurofilament light chain levels in relapsing and progressive MS

ConclusionsCSF NfL levels are increased in RMS and associated with relapses and cortical lesions. Although NfL levels were correlated with Gad+ lesion volume, this association did not persist in multivariable analysis after controlling for previous clinical activity. We encourage controlling for previous clinical activity when testing the association of NfL with MRI. In PMS, the major contributor to NfL was T1-hypointense lesion volume.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research