Expression Patterns of Insulin-Like Growth Factor Binding Protein Isoforms in Medulloblastoma Subtypes and Clinical Correlation

Conclusions: This is the first study to report expression of 3 cancer-related biomarkers - IGFBP-2, -3, -5 in medulloblastoma. Significantly higher extents of expression of IGFBP-3 in large cell variant and IGFBP-5 in classical and anaplastic subtypes suggest a plausible role of these molecules in specific molecular pathways of medulloblastoma.Pediatr Neurosurg
Source: Pediatric Neurosurgery - Category: Neurosurgery Source Type: research