Implications of sequence variation on the evolution of rRNA.

Implications of sequence variation on the evolution of rRNA.
Chromosome Res. 2019 Feb 05;:
Authors: Parks MM, Kurylo CM, Batchelder JE, Theresa Vincent C, Blanchard SC
Abstract
The evolution of the multi-copy family of ribosomal RNA (rRNA) genes is unique in regard to its genetics and genome evolution. Paradoxically, rRNA genes are highly homogenized within and between individuals, yet they are globally distinct between species. Here, we discuss the implications for models of rRNA gene evolution in light of our recent discoveries that ribosomes bearing rRNA sequence variants can affect gene expression and physiology and that intra-individual rRNA alleles exhibit both context- and tissue-specific expression.
PMID: 30719681 [PubMed - as supplied by publisher]

Source: Chromosome Research - February 5, 2019 Category: Genetics & Stem Cells Authors: Parks MM, Kurylo CM, Batchelder JE, Theresa Vincent C, Blanchard SC Tags: Chromosome Res Source Type: research