Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma.

Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma. Intern Med. 2019 Feb 01;: Authors: Ikoma T, Saotome M, Sano M, Suwa K, Naruse Y, Ohtani H, Urushida T, Nagata Y, Ono T, Maekawa Y Abstract Although multiple myeloma (MM) had been an incurable hematological malignancy with a poor prognosis, recent advances in novel anti-neoplastic agents, including carfilzomib (a proteasome inhibitor), have improved the prognosis. We herein report two cases of congestive heart failure in patients treated with carfilzomib. Although there are some reports on the cardiotoxicity of carfilzomib, to our knowledge, this is the first report on the cardiac involvement of carfilzomib in Japanese MM patients. We review the critical points from our two cases, with the aim of avoiding carfilzomib-associated heart failure in MM patients. PMID: 30713316 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research