Lyme nephritis in humans: Physio-pathological bases and spectrum of kidney lesions.
[Lyme nephritis in humans: Physio-pathological bases and spectrum of kidney lesions]. Nephrol Ther. 2019 Jan 31;: Authors: Gueye S, Seck SM, Kane Y, Tosi PO, Dahri S, Kounde C, Algouzmari I, Gouin A, Ged É, Allal A, Rostaing L Abstract Known in less than half a century, borreliosis, or Lyme disease, is a zoonosis caused by the tick bite. It is the most common vector disease in Europe and the United States. Borrelia burgdorferi sensu lato, the bacterium in question, is fitted with a "cunning device" that allows it to trick the immune system and implant the infection chronically. It causes multi-system tissue damage mediated by the inflammatory response of the host. Renal involvement is rarely reported and is better known in dogs as Lyme nephritis. The first case of kidney impairment in the human being was described in 1999, and since then eight other cases have been reported. The involvement is preferentially glomerular; the histological forms vary between immune complex nephropathy and podocytopathy. The pathophysiological mechanisms appear to be triple: immune complex deposits, podocytic hyper-expression of the B7-1 membrane protein, and renal infiltration of inflammatory cells. On the basis of the accumulated knowledge of the disease in just over 40 years, this review aims at establishing the physio-pathological hypotheses of renal involvement in order to better define the histological lesions. PMID: 30713...
A panel to promote an alternative explanation for climate change would be disastrous. Yet that ’s what White House officials wantAmericans should not be fooled by the Stalinist tactics being used by the White House to try to discredit the findings of mainstream climate science.The Trump administration has alreadypurged information about climate change from government websites,gagged federal experts and attempted toend funding for climate change programmes.Continue reading...
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Pancreatic cancer is the third leading cause of death related to cancer in the United States. In contrast to colorectal, breast, and lung cancer, the number of cases are increasing, with pancreatic cancer predicted to become the second most common cause of death due to cancer by 2030.1 The 5-year survival for pancreatic cancer is an abysmal 8.5%.2 One key to improving survival in pancreatic cancer is detecting cancer earlier, with some studies demonstrating survival of almost 60% in patients with stage I cancer.
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Ertem and colleagues1 are to be congratulated on developing an algorithm to estimate the number of postcolonoscopy colorectal cancers (PCCRCs) a colonoscopist will have in his or her lifetime. However, we have concerns about their interpretation of the literature on PCCRC rates and the applicability of their findings to other healthcare settings beyond the United States.
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