Efficacy of Head and Torso Rewarming Using a Human Model for Severe Hypothermia

Publication date: Available online 6 February 2019Source: Wilderness &Environmental MedicineAuthor(s): Kartik Kulkarni, Erik Hildahl, Ramesh Dutta, Sandra C. Webber, Steven Passmore, Gerren K McDonald, Gordon G. GiesbrechtIntroductionTo evaluate the rewarming effectiveness of a similar amount of heat (from a charcoal heater) applied to either the head or torso in a human model for severe hypothermia in which shivering is pharmacologically inhibited in mildly hypothermic subjects.MethodsSix male subjects were cooled on 3 different occasions, each in 8°C water for 60 min, or to a lowest core temperature of 35°C. Shivering was inhibited by intravenous meperidine (1.5 mg·kg−1), administered during the last 10 min of the cold-water immersion. Subjects then exited from the cold water, were dried, and were placed in a 3-season sleeping bag for 120 min in one of the following conditions: spontaneous rewarming only, charcoal heater on the head, or charcoal heater on the torso. Supplemental meperidine (to a maximum cumulative dose of 3.3 mg·kg−1) was administered as required during rewarming to suppress shivering.ResultsNo significant differences were found in the postcooling afterdrop amount or core rewarming rates among the 3 conditions (0.8°C·h−1). During the last 30 min of rewarming the net heat gain was significantly higher in the head (85.8±25.3 W) and torso (81.5±6.3 W) conditions compared with the spontaneous ...
Source: Wilderness and Environmental Medicine - Category: Environmental Health Source Type: research

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Publication date: Available online 17 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Julius Griauzde, Vijay M. Ravindra, Neeraj Chaudhary, Joseph J. Gemmete, Aditya S. PandeyAbstractMechanical thrombectomy is now at the forefront of the treatment of large vessel acute ischemic stroke (AIS). Selective intra-arterial (IA) access has opened a new avenue for neuroprotection in AIS that has the potential to maximize local benefit while minimizing systemic effects. On a cellular level, neuroprotective strategies are aimed at reducing inflammation and free-radical formation, maintaining blood-brain barrier fidelity...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
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Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Original Articles Source Type: research
Conclusion There was a decrease in metabolic demand as measured by oxygen requirement, OI, HR, and MBP during WBH, but only HR increased during rewarming, with no significant change in the other parameters. Some of this effect may be explained by improvement in the respiratory condition over time. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
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Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
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Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
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Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
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Source: Critical Care Research and Practice - Category: Intensive Care Tags: Crit Care Res Pract Source Type: research
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