Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury

In this study, we investigated the vascular-protective effect of the DPP-4 inhibitor, linagliptin, using vascular smooth muscle cells (VSMCs). Methods: Six-week-old male C57BL/6 mice were divided into control (n =19) and linagliptin (3 mg/kg/day, n =20) treated groups. Endothelial denudation injuries were induced in the femoral artery at 8 weeks of age, followed by evaluation of neointima formation at 12 weeks. To evaluate cell proliferation of rat aortic smooth muscle cells, a bromodeoxyuridine (BrdU) incorporation assay was performed. Results: Linagliptin treatment reduced vascular injury-induced neointima formation, compared with controls (p
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research