Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex.

CONCLUSIONS: These findings suggest that MIA can lead to impairments in cognitive flexibility in mice similar to those exhibited in ASD individuals, and that these impairments are associated with altered gene expression in frontal cortex. PMID: 30716470 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30716470?dopt=Abstract

Source: Neurobiology of Disease - February 1, 2019 Category: Neurology Authors: Amodeo DA, Lai CY, Hassan O, Mukamel EA, Behrens MM, Powell SB Tags: Neurobiol Dis Source Type: research