[Functionalization of Cyclodextrin Derivatives to Create Supramolecular Pharmaceutical Materials].

[Functionalization of Cyclodextrin Derivatives to Create Supramolecular Pharmaceutical Materials]. Yakugaku Zasshi. 2019;139(2):165-173 Authors: Osaki M Abstract Molecular recognition is useful in creating functional supramolecular materials. Non-covalent bond formations, such as host-guest interactions, hydrogen bonding, and electrostatic interaction, are effective tools for introducing various functions and properties into materials. This review focuses on such macroscopic functions as selective molecular adhesion, self-healing, toughness, and the actuation of supramolecular polymeric materials-materials which have potential in pharmaceutical development. These functions have been achieved using reversible bonding between cyclodextrins (CDs; cyclic host molecules) and guest molecules. For example, macroscopic adhesions between host-modified hydrogels and guest-modified hydrogels have been investigated. CD-modified hydrogels were found to show selective adhesion to a guest hydrogel with an appropriate molecular size for the CD cavity, indicating that the host-guest complex formation between the gels led to the adhesive behavior. Surprisingly, polymeric materials having host-guest cross-linking points show both high toughness and flexibility, unlike conventional covalently cross-linked materials. These materials also exhibited self-healing properties, capable of repairing damage to the materials. Furthermore, the supramolecular mater...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research